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Tapt1 transmembrane anterior posterior transformation 1 [ Mus musculus (house mouse) ]

Gene ID: 231225, updated on 2-Nov-2024

Summary

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Official Symbol
Tapt1provided by MGI
Official Full Name
transmembrane anterior posterior transformation 1provided by MGI
Primary source
MGI:MGI:2683537
See related
Ensembl:ENSMUSG00000046985 AllianceGenome:MGI:2683537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4932414K18Rik
Summary
Acts upstream of or within embryonic skeletal system development. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be active in ciliary basal body and endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; genitourinary system; liver; lung; and retina layer. Orthologous to human TAPT1 (transmembrane anterior posterior transformation 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 24.6), mammary gland adult (RPKM 10.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tapt1 in Genome Data Viewer
Location:
5 B3; 5 24.24 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (44332496..44384411, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (44175154..44231163, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35900 Neighboring gene STARR-seq mESC enhancer starr_12986 Neighboring gene STARR-seq mESC enhancer starr_12987 Neighboring gene predicted gene 42427 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:44611861-44612044 Neighboring gene predicted gene, 35959 Neighboring gene STARR-seq mESC enhancer starr_12989 Neighboring gene predicted gene, 40296 Neighboring gene STARR-seq mESC enhancer starr_12990

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transmembrane anterior posterior transformation 1 regulates BMP signaling and modulates the protein stability of SMAD1/5. Wang B, et al. J Biol Chem, 2022 Dec. PMID 36370851, Free PMC Article
  2. Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations. Howell GR, et al. Genetics, 2007 Feb. PMID 17151244, Free PMC Article
  3. High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5. Ching YH, et al. BMC Genet, 2010 Nov 30. PMID 21118569, Free PMC Article
  4. Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations. Wilson L, et al. Genome Res, 2005 Aug. PMID 16024820, Free PMC Article
  5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transmembrane anterior posterior transformation 1 regulates BMP signaling and modulates the protein stability of SMAD1/5.
    Title: Transmembrane anterior posterior transformation 1 regulates BMP signaling and modulates the protein stability of SMAD1/5.
  2. TAPT1 is a downstream effector of HOXC8 that may act by transducing or transmitting extracellular information required for axial skeletal patterning during development.
    Title: Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Targeted (1) 
  • Transgenic (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anatomical structure development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cartilage development IEA
Inferred from Electronic Annotation
more info
  
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neural crest cell development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of bone development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cartilage development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane anterior posterior transformation protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173764.3 → NP_776125.2  transmembrane anterior posterior transformation protein 1

    See identical proteins and their annotated locations for NP_776125.2

    Status: VALIDATED

    Source sequence(s)
    BC096038, CN459607
    Consensus CDS
    CCDS19270.1
    UniProtKB/Swiss-Prot
    Q4VBD2, Q8CDI4
    Related
    ENSMUSP00000062110.8, ENSMUST00000055128.12
    Conserved Domains (1) summary
    pfam05346
    Location:152 → 456
    DUF747; Eukaryotic membrane protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    44332496..44384411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503940.3 → XP_006504003.1  transmembrane anterior posterior transformation protein 1 isoform X1

    Conserved Domains (1) summary
    pfam05346
    Location:146 → 450
    DUF747; Eukaryotic membrane protein family

  2. XM_030254388.1 → XP_030110248.1  transmembrane anterior posterior transformation protein 1 isoform X2

    Conserved Domains (1) summary
    pfam05346
    Location:1 → 285
    DUF747; Eukaryotic membrane protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VBD2.2 GenPept UniProtKB/Swiss-Prot:Q4VBD2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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