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KDM4C lysine demethylase 4C [ Homo sapiens (human) ]

Gene ID: 23081, updated on 14-Nov-2024

Summary

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Official Symbol
KDM4Cprovided by HGNC
Official Full Name
lysine demethylase 4Cprovided by HGNC
Primary source
HGNC:HGNC:17071
See related
Ensembl:ENSG00000107077 MIM:605469; AllianceGenome:HGNC:17071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GASC1; JHDM3C; JMJD2C; TDRD14C
Summary
This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form. This enzymatic action regulates gene expression and chromosome segregation. Chromosomal aberrations and changes in expression of this gene may be found in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in lymph node (RPKM 3.4), bone marrow (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

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See KDM4C in Genome Data Viewer
Location:
9p24.1
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (6720863..7175648)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (6715554..7172114)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (6720863..7175648)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28200 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:6707295-6707509 Neighboring gene uncharacterized LOC124902117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28203 Neighboring gene long intergenic non-protein coding RNA 2851 Neighboring gene PRELI domain containing 3B pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28205 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:6756064-6756775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19770 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:6761325-6762007 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6766791-6767436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6767437-6768080 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6771154-6772127 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6775214-6775806 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6776399-6776990 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:6776991-6777582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6789083-6789798 Neighboring gene SNRPE pseudogene 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:6808287-6808846 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:6834601-6835322 Neighboring gene actin gamma 1 pseudogene 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6940065-6940565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:7147699-7148200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:7148201-7148700 Neighboring gene NANOG hESC enhancer GRCh37_chr9:7185598-7186113 Neighboring gene uncharacterized LOC105375969 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:7240589-7241138 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:7284400-7285015 Neighboring gene uncharacterized LOC105375970 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:7319761-7320960 Neighboring gene uncharacterized LOC102723994

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Kim TD, et al. Am J Transl Res, 2014. PMID 24936217, Free PMC Article
  2. Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis. Ortiz-Fernández L, et al. Ann Rheum Dis, 2018 Apr. PMID 29374629, Free PMC Article
  3. KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer. Garcia J, et al. Breast Cancer (Auckl), 2016. PMID 27840577, Free PMC Article
  4. KDM4C, a H3K9me3 Histone Demethylase, is Involved in the Maintenance of Human ESCC-Initiating Cells by Epigenetically Enhancing SOX2 Expression. Yuan X, et al. Neoplasia, 2016 Oct. PMID 27742014, Free PMC Article
  5. JMJD2C promotes colorectal cancer metastasis via regulating histone methylation of MALAT1 promoter and enhancing β-catenin signaling pathway. Wu X, et al. J Exp Clin Cancer Res, 2019 Oct 29. PMID 31665047, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis.
    Title: The promotive role of lncRNA MIR205HG in proliferation, invasion, and migration of melanoma cells via the JMJD2C/ALKBH5 axis.
  2. KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations.
    Title: KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations.
  3. The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2[V617F] mutated cells.
    Title: The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2(V617F) mutated cells.
  4. Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.
    Title: Focal structural variants revealed by whole genome sequencing disrupt the histone demethylase KDM4C in B-cell lymphomas.
  5. KDM4C in germinal center lymphoma: a new piece of the epigenetic puzzle.
    Title: KDM4C in germinal center lymphoma: a new piece of the epigenetic puzzle.
  6. Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury.
    Title: Essential Roles of the Histone Demethylase KDM4C in Renal Development and Acute Kidney Injury.
  7. Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype.
    Title: Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype.
  8. Histone Demethylase GASC1 Inhibitor Targeted GASC1 Gene to Inhibit the Malignant Transformation of Esophageal Cancer through the NOTCH-MAPK Signaling Pathway.
    Title: Histone Demethylase GASC1 Inhibitor Targeted GASC1 Gene to Inhibit the Malignant Transformation of Esophageal Cancer through the NOTCH-MAPK Signaling Pathway.
  9. JMJD2C-mediated long non-coding RNA MALAT1/microRNA-503-5p/SEPT2 axis worsens non-small cell lung cancer.
    Title: JMJD2C-mediated long non-coding RNA MALAT1/microRNA-503-5p/SEPT2 axis worsens non-small cell lung cancer.
  10. Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism.
    Title: Inhibition of KDM4C/c-Myc/LDHA signalling axis suppresses prostate cancer metastasis via interference of glycolytic metabolism.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
EBI GWAS Catalog
Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25668, FLJ25949, KIAA0780

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables histone H3K36 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K36 demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K9 demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9 demethylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K9me2/H3K9me3 demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K9me2/H3K9me3 demethylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone demethylase activity EXP
Inferred from Experiment
more info
 PubMed 
enables histone demethylase activity TAS
Traceable Author Statement
more info
  
enables nuclear androgen receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear receptor coactivator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in blastocyst formation IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of androgen receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pericentric heterochromatin IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysine-specific demethylase 4C
Names
JmjC domain-containing histone demethylation protein 3C
[histone H3]-trimethyl-L-lysine(9) demethylase 4C
gene amplified in squamous cell carcinoma 1 protein
jumonji domain-containing protein 2C
lysine (K)-specific demethylase 4C
tudor domain containing 14C
NP_001140167.1
NP_001140168.1
NP_001291268.1
NP_001291269.1
NP_001291270.1
NP_001340926.1
NP_001340927.1
NP_001340928.1
NP_001340929.1
NP_001340930.1
NP_055876.2
XP_016869987.1
XP_047278982.1
XP_047278983.1
XP_047278984.1
XP_047278985.1
XP_047278986.1
XP_054218414.1
XP_054218415.1
XP_054218416.1
XP_054218417.1
XP_054218418.1
XP_054218419.1
XP_054218420.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146695.4 → NP_001140167.1  lysine-specific demethylase 4C isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL354707, AL445592, AL513412
    Consensus CDS
    CCDS55286.1
    UniProtKB/Swiss-Prot
    Q9H3R0
    Related
    ENSP00000445427.1, ENST00000543771.5
    Conserved Domains (4) summary
    cd15577
    Location:644 → 746
    PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    pfam02373
    Location:177 → 293
    JmjC; JmjC domain, hydroxylase
    cl15840
    Location:16 → 57
    JmjN; jmjN domain
    cl22851
    Location:755 → 808
    PHD_SF; PHD finger superfamily

  2. NM_001146696.2 → NP_001140168.1  lysine-specific demethylase 4C isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL354707, AL445592, AL513412
    Consensus CDS
    CCDS55285.1
    UniProtKB/Swiss-Prot
    Q9H3R0
    Conserved Domains (4) summary
    cd15577
    Location:666 → 768
    PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    pfam02373
    Location:199 → 315
    JmjC; JmjC domain, hydroxylase
    cl15840
    Location:38 → 79
    JmjN; jmjN domain
    cl22851
    Location:777 → 830
    PHD_SF; PHD finger superfamily

  3. NM_001304339.4 → NP_001291268.1  lysine-specific demethylase 4C isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL161443, AL354707, AL445592, AL513412
    Related
    ENSP00000370707.3, ENST00000381306.7
    Conserved Domains (6) summary
    cd15577
    Location:644 → 746
    PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    cd15715
    Location:755 → 864
    ePHD_JMJD2C; Extended PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    pfam02373
    Location:177 → 293
    JmjC; JmjC domain, hydroxylase
    cd20465
    Location:879 → 932
    Tudor_JMJD2C_rpt1; first Tudor domain found in Jumonji domain-containing protein 2C (JMJD2C) and similar proteins
    cd20468
    Location:936 → 995
    Tudor_JMJD2C_rpt2; second Tudor domain found in Jumonji domain-containing protein 2C (JMJD2C) and similar proteins
    cl15840
    Location:16 → 57
    JmjN; jmjN domain

  4. NM_001304340.4 → NP_001291269.1  lysine-specific demethylase 4C isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL161443, AL354707, AL445592, AL513412
    UniProtKB/TrEMBL
    B4E239
    Conserved Domains (5) summary
    cd15577
    Location:389 → 491
    PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    pfam02373
    Location:1 → 112
    JmjC; JmjC domain, hydroxylase
    cd20465
    Location:624 → 677
    Tudor_JMJD2C_rpt1; first Tudor domain found in Jumonji domain-containing protein 2C (JMJD2C) and similar proteins
    cd20468
    Location:681 → 740
    Tudor_JMJD2C_rpt2; second Tudor domain found in Jumonji domain-containing protein 2C (JMJD2C) and similar proteins
    cl22851
    Location:500 → 609
    PHD_SF; PHD finger superfamily

  5. NM_001304341.4 → NP_001291270.1  lysine-specific demethylase 4C isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL354707
    Consensus CDS
    CCDS78379.1
    UniProtKB/TrEMBL
    B0QZ60
    Related
    ENSP00000383990.3, ENST00000401787.7
    Conserved Domains (1) summary
    cl15840
    Location:16 → 57
    JmjN; jmjN domain

  6. NM_001353997.3 → NP_001340926.1  lysine-specific demethylase 4C isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL161443, AL354707, AL445592, AL513412
    Conserved Domains (5) summary
    smart00333
    Location:912 → 966
    TUDOR; Tudor domain
    pfam02373
    Location:177 → 293
    JmjC; JmjC domain, hydroxylase
    cd15577
    Location:644 → 746
    PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    cd15715
    Location:755 → 864
    ePHD_JMJD2C; Extended PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    cl15840
    Location:16 → 57
    JmjN; jmjN domain

  7. NM_001353998.3 → NP_001340927.1  lysine-specific demethylase 4C isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL354707, AL445592, AL513412
    Conserved Domains (4) summary
    pfam02373
    Location:177 → 293
    JmjC; JmjC domain, hydroxylase
    cd15577
    Location:644 → 746
    PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    cl15840
    Location:16 → 57
    JmjN; jmjN domain
    cl22851
    Location:755 → 772
    PHD_SF; PHD finger superfamily

  8. NM_001353999.3 → NP_001340928.1  lysine-specific demethylase 4C isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL161443, AL354707, AL445592, AL513412
    UniProtKB/TrEMBL
    C9J879
    Conserved Domains (3) summary
    smart00333
    Location:475 → 529
    TUDOR; Tudor domain
    cd15577
    Location:207 → 309
    PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    cl22851
    Location:318 → 427
    PHD_SF; PHD finger superfamily

  9. NM_001354000.3 → NP_001340929.1  lysine-specific demethylase 4C isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL161443, AL354707, AL445592, AL513412
    UniProtKB/TrEMBL
    C9J879
    Conserved Domains (3) summary
    smart00333
    Location:442 → 496
    TUDOR; Tudor domain
    cd15577
    Location:207 → 309
    PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    cl22851
    Location:318 → 427
    PHD_SF; PHD finger superfamily

  10. NM_001354001.3 → NP_001340930.1  lysine-specific demethylase 4C isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL161443, AL354707, AL445592, AL513412
    UniProtKB/TrEMBL
    C9J879
    Conserved Domains (3) summary
    smart00333
    Location:442 → 496
    TUDOR; Tudor domain
    cd15577
    Location:207 → 309
    PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    cl22851
    Location:318 → 427
    PHD_SF; PHD finger superfamily

  11. NM_015061.6 → NP_055876.2  lysine-specific demethylase 4C isoform 1

    See identical proteins and their annotated locations for NP_055876.2

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL161443, AL354707, AL445592, AL513412
    Consensus CDS
    CCDS6471.1
    UniProtKB/Swiss-Prot
    B4E1Y4, B7ZL46, F5H347, F5H7P0, O94877, Q2M3M0, Q5JUC9, Q5VYJ2, Q5VYJ3, Q9H3R0
    Related
    ENSP00000370710.3, ENST00000381309.8
    Conserved Domains (5) summary
    smart00333
    Location:879 → 933
    TUDOR; Tudor domain
    pfam02373
    Location:177 → 293
    JmjC; JmjC domain, hydroxylase
    cd15577
    Location:644 → 746
    PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    cd15715
    Location:755 → 864
    ePHD_JMJD2C; Extended PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    cl15840
    Location:16 → 57
    JmjN; jmjN domain

RNA

  1. NR_130707.4 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL354707, AL445592, AL513412
    Related
    ENST00000438023.5

  2. NR_148677.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL161443, AL354707, AL445592, AL513412

  3. NR_148678.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL161443, AL354707, AL445592, AL513412

  4. NR_148679.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL161443, AL354707, AL445592, AL513412

  5. NR_148680.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137020, AL161443, AL354707, AL445592, AL513412

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    6720863..7175648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014498.3 → XP_016869987.1  lysine-specific demethylase 4C isoform X1

    Conserved Domains (5) summary
    smart00333
    Location:878 → 933
    TUDOR; Tudor domain
    pfam02373
    Location:177 → 293
    JmjC; JmjC domain, hydroxylase
    cd15577
    Location:644 → 746
    PHD_JMJD2C; PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    cd15715
    Location:755 → 864
    ePHD_JMJD2C; Extended PHD finger found in Jumonji domain-containing protein 2C (JMJD2C)
    cl15840
    Location:16 → 57
    JmjN; jmjN domain

  2. XM_047423029.1 → XP_047278985.1  lysine-specific demethylase 4C isoform X2

  3. XM_047423028.1 → XP_047278984.1  lysine-specific demethylase 4C isoform X3

  4. XM_047423027.1 → XP_047278983.1  lysine-specific demethylase 4C isoform X2

  5. XM_047423026.1 → XP_047278982.1  lysine-specific demethylase 4C isoform X2

  6. XM_047423030.1 → XP_047278986.1  lysine-specific demethylase 4C isoform X4

    Related
    ENSP00000405739.2, ENST00000428870.6

RNA

  1. XR_001746255.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    6715554..7172114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362439.1 → XP_054218414.1  lysine-specific demethylase 4C isoform X1

  2. XM_054362445.1 → XP_054218420.1  lysine-specific demethylase 4C isoform X5

  3. XM_054362443.1 → XP_054218418.1  lysine-specific demethylase 4C isoform X2

  4. XM_054362442.1 → XP_054218417.1  lysine-specific demethylase 4C isoform X3

  5. XM_054362441.1 → XP_054218416.1  lysine-specific demethylase 4C isoform X2

  6. XM_054362440.1 → XP_054218415.1  lysine-specific demethylase 4C isoform X2

  7. XM_054362444.1 → XP_054218419.1  lysine-specific demethylase 4C isoform X4

RNA

  1. XR_008487968.1 RNA Sequence

  2. XR_008487969.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001146694.1: Suppressed sequence

    Description
    NM_001146694.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H3R0.2 GenPept UniProtKB/Swiss-Prot:Q9H3R0

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