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Zp3r zona pellucida 3 receptor [ Mus musculus (house mouse) ]

Gene ID: 22789, updated on 2-Nov-2024

Summary

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Official Symbol
Zp3rprovided by MGI
Official Full Name
zona pellucida 3 receptorprovided by MGI
Primary source
MGI:MGI:104965
See related
Ensembl:ENSMUSG00000042554 AllianceGenome:MGI:104965
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SP56
Summary
Involved in binding activity of sperm to zona pellucida. Acts upstream of or within single fertilization. Located in acrosomal vesicle; cell body; and plasma membrane. Part of zona pellucida receptor complex. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 24.4) See more
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Genomic context

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See Zp3r in Genome Data Viewer
Location:
1 E4; 1 56.89 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130474847..130557371, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130547110..130629634, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CD55 molecule, decay accelerating factor for complement B Neighboring gene CD55 molecule, opposite strand sequence Neighboring gene CD55 molecule, decay accelerating factor for complement Neighboring gene STARR-positive B cell enhancer ABC_E9183 Neighboring gene STARR-positive B cell enhancer ABC_E7745 Neighboring gene STARR-seq mESC enhancer starr_02195 Neighboring gene predicted gene 16083 Neighboring gene STARR-positive B cell enhancer ABC_E11084 Neighboring gene STARR-seq mESC enhancer starr_02198 Neighboring gene STARR-positive B cell enhancer mm9_chr1:132472703-132473004 Neighboring gene STARR-seq mESC enhancer starr_02199 Neighboring gene predicted gene, 23623 Neighboring gene STARR-seq mESC enhancer starr_02200 Neighboring gene complement component 4 binding protein Neighboring gene complement component 4 binding protein, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sperm-egg recognition in the mouse: characterization of sp56, a sperm protein having specific affinity for ZP3. Cheng A, et al. J Cell Biol, 1994 May. PMID 8188752, Free PMC Article
  2. Recombinant mouse sperm ZP3-binding protein (ZP3R/sp56) forms a high order oligomer that binds eggs and inhibits mouse fertilization in vitro. Buffone MG, et al. J Biol Chem, 2008 May 2. PMID 18316377, Free PMC Article
  3. Functional consequences of cleavage, dissociation and exocytotic release of ZP3R, a C4BP-related protein, from the mouse sperm acrosomal matrix. Buffone MG, et al. J Cell Sci, 2009 Sep 1. PMID 19654207, Free PMC Article
  4. Function of the acrosomal matrix: zona pellucida 3 receptor (ZP3R/sp56) is not essential for mouse fertilization. Muro Y, et al. Biol Reprod, 2012 Jan. PMID 21998167, Free PMC Article
  5. Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc(-/-) globozoospermic spermatogenesis. Bizkarguenaga M, et al. Microsc Res Tech, 2022 Apr. PMID 34870349

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc(-/-) globozoospermic spermatogenesis.
    Title: Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc(-/-) globozoospermic spermatogenesis.
  2. These results provide further evidence that either ZP3R is not involved in sperm-zona pellucida binding or this process might be functionally redundant, involving multiple proteins for gamete interactions.
    Title: Function of the acrosomal matrix: zona pellucida 3 receptor (ZP3R/sp56) is not essential for mouse fertilization.
  3. ZP3R monomer is processed from 67,000 M(r) to 43,000 M(r) by proteases coincident with release from the acrosome.
    Title: Functional consequences of cleavage, dissociation and exocytotic release of ZP3R, a C4BP-related protein, from the mouse sperm acrosomal matrix.
  4. These results indicate that sperm ZP3R/sp56 is important for sperm-zona interactions during fertilization and support the concept that the acrosomal matrix plays an essential role in mediating the binding of sperm to the zona pellucida.
    Title: Recombinant mouse sperm ZP3-binding protein (ZP3R/sp56) forms a high order oligomer that binds eggs and inhibits mouse fertilization in vitro.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell mediated immunity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within binding of sperm to zona pellucida IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in binding of sperm to zona pellucida IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in binding of sperm to zona pellucida IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in binding of sperm to zona pellucida ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of complement activation, classical pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of opsonization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to symbiotic bacterium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within single fertilization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal lumen IEA
Inferred from Electronic Annotation
more info
  
located_in acrosomal matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal matrix ISO
Inferred from Sequence Orthology
more info
  
located_in acrosomal vesicle EXP
Inferred from Experiment
more info
 PubMed 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in outer acrosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of zona pellucida receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zona pellucida sperm-binding protein 3 receptor
Names
sperm fertilization protein 56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420657.1 → NP_001407586.1  zona pellucida sperm-binding protein 3 receptor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109283, AC122773
    Related
    ENSMUSP00000114401.2, ENSMUST00000128128.8

  2. NM_009581.3 → NP_033607.2  zona pellucida sperm-binding protein 3 receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_033607.2

    Status: VALIDATED

    Source sequence(s)
    AC109283, AC122773
    Consensus CDS
    CCDS15257.1
    UniProtKB/Swiss-Prot
    Q60736
    UniProtKB/TrEMBL
    G3X970, Q0VET1
    Related
    ENSMUSP00000045443.5, ENSMUST00000039862.11
    Conserved Domains (4) summary
    cd00033
    Location:158 → 219
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:350 → 411
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:153 → 411
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:283 → 343
    Sushi; Sushi repeat (SCR repeat)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130474847..130557371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247992.3 → XP_011246294.1  zona pellucida sperm-binding protein 3 receptor isoform X2

    Conserved Domains (3) summary
    smart00032
    Location:371 → 432
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    PHA02927
    Location:71 → 299
    PHA02927; secreted complement-binding protein; Provisional
    pfam00084
    Location:304 → 364
    Sushi; Sushi repeat (SCR repeat)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60736.1 GenPept UniProtKB/Swiss-Prot:Q60736

Gene LinkOut

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