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FHL1 four and a half LIM domains 1 [ Homo sapiens (human) ]

Gene ID: 2273, updated on 14-Nov-2024

Summary

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Official Symbol
FHL1provided by HGNC
Official Full Name
four and a half LIM domains 1provided by HGNC
Primary source
HGNC:HGNC:3702
See related
Ensembl:ENSG00000022267 MIM:300163; AllianceGenome:HGNC:3702
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KYOT; SLIM; FCMSU; FHL-1; FHL1A; FHL1B; FLH1A; SLIM1; XMPMA; RBMX1A; RBMX1B; SLIM-1; SLIMMER
Summary
This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]
Expression
Broad expression in heart (RPKM 286.6), fat (RPKM 281.6) and 18 other tissues See more
Orthologs
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Genomic context

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See FHL1 in Genome Data Viewer
Location:
Xq26.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (136146702..136211359)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134455091..134519750)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135228861..135293518)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:135179522-135180721 Neighboring gene E2F transcription factor 6 pseudogene 4 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:135196669-135196868 Neighboring gene small nucleolar RNA U13 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:135225551-135226750 Neighboring gene Sharpr-MPRA regulatory region 1893 Neighboring gene MAP7 domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21026 Neighboring gene serine/threonine kinase 24 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration. Clark SJ, et al. J Immunol, 2014 Nov 15. PMID 25305316, Free PMC Article
  2. Reducing bodies and myofibrillar myopathy features in FHL1 muscular dystrophy. Selcen D, et al. Neurology, 2011 Nov 29. PMID 22094483, Free PMC Article
  3. Expression of FHL1 in gastric cancer tissue and its correlation with the invasion and metastasis of gastric cancer. Xu Y, et al. Mol Cell Biochem, 2012 Apr. PMID 22143536
  4. Selective muscle involvement in a family affected by a second LIM domain mutation of fhl1: an imaging study using computed tomography. Komagamine T, et al. J Neurol Sci, 2012 Jul 15. PMID 22541254
  5. FHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect. Asada K, et al. Oncogene, 2013 Apr 25. PMID 22689052

See all (174) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FHL1: A novel diagnostic marker for papillary thyroid carcinoma.
    Title: FHL1: A novel diagnostic marker for papillary thyroid carcinoma.
  2. Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer.
    Title: Low FHL1 expression indicates a good prognosis and drug sensitivity in ovarian cancer.
  3. Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.
    Title: Immortalization-upregulated protein promotes pancreatic cancer progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint protein activity.
  4. Identification of novel FHL1 mutations associated with X-linked scapuloperoneal myopathy in unrelated Chinese patients.
    Title: Identification of novel FHL1 mutations associated with X-linked scapuloperoneal myopathy in unrelated Chinese patients.
  5. Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells.
    Title: Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells.
  6. FHL1 as a novel prognostic biomarker and correlation with immune infiltration levels in lung adenocarcinoma.
    Title: FHL1 as a novel prognostic biomarker and correlation with immune infiltration levels in lung adenocarcinoma.
  7. Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells.
    Title: Targeting FHL1 impairs cell proliferation and differentiation of acute myeloid leukemia cells.
  8. MiR-96-5p Facilitates Lung Adenocarcinoma Cell Phenotypes by Inhibiting FHL1.
    Title: MiR-96-5p Facilitates Lung Adenocarcinoma Cell Phenotypes by Inhibiting FHL1.
  9. Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.
    Title: Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.
  10. Three novel FHL1 variants cause a mild phenotype of Emery-Dreifuss muscular dystrophy.
    Title: Three novel FHL1 variants cause a mild phenotype of Emery-Dreifuss muscular dystrophy.
Submit: New GeneRIF Correction See all GeneRIFs (84)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC111107

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in muscle organ development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of membrane depolarization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of potassium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in focal adhesion HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
four and a half LIM domains protein 1
Names
LIM protein SLIMMER
four-and-a-half Lin11, Isl-1 and Mec-3 domains 1
skeletal muscle LIM-protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015895.1 RefSeqGene

    Range
    5134..68955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_739

mRNA and Protein(s)

  1. NM_001159699.2 → NP_001153171.1  four and a half LIM domains protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001153171.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, 3' UTR, and 3' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 5) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    BC088369, BM995585, DC373386
    Consensus CDS
    CCDS55506.1
    UniProtKB/TrEMBL
    Q53FI7
    Related
    ENSP00000359717.1, ENST00000370683.6
    Conserved Domains (5) summary
    cd09344
    Location:56 → 109
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:233 → 296
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:117 → 174
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:178 → 230
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:21 → 49
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001159700.2 → NP_001153172.1  four and a half LIM domains protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001153172.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
    Source sequence(s)
    AK304680, AL078638, BC088369, BM995585, DC363191
    Consensus CDS
    CCDS14655.1
    UniProtKB/TrEMBL
    Q53FI7
    Related
    ENSP00000485897.1, ENST00000630084.2
    Conserved Domains (5) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217 → 280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. NM_001159701.2 → NP_001153173.1  four and a half LIM domains protein 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001153173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR, and coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 3) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK301642, BC010998, BM995585
    Consensus CDS
    CCDS55505.1
    UniProtKB/TrEMBL
    Q53FI7
    Related
    ENSP00000437673.1, ENST00000539015.5
    Conserved Domains (5) summary
    cd09344
    Location:69 → 122
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:246 → 309
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:130 → 187
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:191 → 243
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:34 → 62
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  4. NM_001159702.3 → NP_001153174.1  four and a half LIM domains protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001153174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AF063002, AF098518, BC010998, BM995585
    Consensus CDS
    CCDS55507.1
    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
    Related
    ENSP00000377710.2, ENST00000394155.8
    Conserved Domains (4) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  5. NM_001159703.2 → NP_001153175.1  four and a half LIM domains protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001153175.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.
    Source sequence(s)
    AF220153, AK301642, AL078638, BC010998, BE965488, BM995585, DA497183
    Consensus CDS
    CCDS76036.1
    UniProtKB/TrEMBL
    A0A0D9SFZ9
    Related
    ENSP00000477609.1, ENST00000618438.4
    Conserved Domains (3) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  6. NM_001159704.1 → NP_001153176.1  four and a half LIM domains protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001153176.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
    Source sequence(s)
    AK122708, AL078638, BM995585
    Consensus CDS
    CCDS14655.1
    UniProtKB/TrEMBL
    Q53FI7
    Related
    ENSP00000443333.1, ENST00000543669.5
    Conserved Domains (5) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217 → 280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  7. NM_001167819.1 → NP_001161291.1  four and a half LIM domains protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001161291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses a different segment for its 5' UTR and lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
    Source sequence(s)
    BC010998, BM995585, DA917361, DA982372
    Consensus CDS
    CCDS14655.1
    UniProtKB/TrEMBL
    Q53FI7
    Related
    ENSP00000377709.2, ENST00000394153.6
    Conserved Domains (5) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217 → 280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  8. NM_001330659.2 → NP_001317588.1  four and a half LIM domains protein 1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate 5'-terminal exon, lacks two in-frame exons in the 3' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL078638
    Consensus CDS
    CCDS83493.1
    UniProtKB/TrEMBL
    A0A0D9SFZ9, Q5JXI2
    Related
    ENSP00000359710.3, ENST00000370676.7
    Conserved Domains (3) summary
    cd09344
    Location:56 → 109
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:117 → 174
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:21 → 49
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  9. NM_001369326.1 → NP_001356255.1  four and a half LIM domains protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL078638
    Consensus CDS
    CCDS55507.1
    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
    Related
    ENSP00000498684.1, ENST00000651089.1
    Conserved Domains (4) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  10. NM_001369327.2 → NP_001356256.1  four and a half LIM domains protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL078638
    Consensus CDS
    CCDS55507.1
    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
    Conserved Domains (4) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  11. NM_001369328.1 → NP_001356257.1  four and a half LIM domains protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL078638
    Consensus CDS
    CCDS55507.1
    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
    Conserved Domains (4) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  12. NM_001369329.1 → NP_001356258.1  four and a half LIM domains protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL078638
    Consensus CDS
    CCDS14655.1
    UniProtKB/TrEMBL
    Q53FI7
    Conserved Domains (5) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217 → 280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  13. NM_001369330.1 → NP_001356259.1  four and a half LIM domains protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL078638
    Consensus CDS
    CCDS14655.1
    UniProtKB/TrEMBL
    Q53FI7
    Related
    ENSP00000444815.1, ENST00000535737.5
    Conserved Domains (5) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217 → 280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  14. NM_001369331.1 → NP_001356260.1  four and a half LIM domains protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL078638
    Consensus CDS
    CCDS14655.1
    UniProtKB/TrEMBL
    Q53FI7
    Related
    ENSP00000359708.1, ENST00000370674.3
    Conserved Domains (5) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217 → 280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  15. NM_001449.5 → NP_001440.2  four and a half LIM domains protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001440.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1. The encoded protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. Variants 2, 3, 4 and 9 encode the same protein (isoform 2).
    Source sequence(s)
    BC010998, BM995585
    Consensus CDS
    CCDS14655.1
    UniProtKB/TrEMBL
    Q53FI7
    Related
    ENSP00000499016.1, ENST00000651929.2
    Conserved Domains (5) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217 → 280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RNA

  1. NR_027621.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) includes an additional exon at the 5' end, compared to variant 1. This variant is represented as non-coding because it contains an upstream ORF that is predicted to interfere with translation of the downstream expected ORF as used in variant 1.
    Source sequence(s)
    AK289411, AL078638, BC010998, BM995585

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    136146702..136211359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441926.1 → XP_047297882.1  four and a half LIM domains protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

  2. XM_047441927.1 → XP_047297883.1  four and a half LIM domains protein 1 isoform X3

  3. XM_024452354.2 → XP_024308122.1  four and a half LIM domains protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
    Conserved Domains (4) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  4. XM_047441925.1 → XP_047297881.1  four and a half LIM domains protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

  5. XM_006724743.3 → XP_006724806.1  four and a half LIM domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006724806.1

    Conserved Domains (4) summary
    cd09344
    Location:56 → 109
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:117 → 174
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:178 → 230
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:21 → 49
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  6. XM_006724746.4 → XP_006724809.1  four and a half LIM domains protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006724809.1

    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
    Conserved Domains (4) summary
    cd09344
    Location:40 → 93
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101 → 158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162 → 214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    134455091..134519750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326701.1 → XP_054182676.1  four and a half LIM domains protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

  2. XM_054326702.1 → XP_054182677.1  four and a half LIM domains protein 1 isoform X3

  3. XM_054326700.1 → XP_054182675.1  four and a half LIM domains protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

  4. XM_054326699.1 → XP_054182674.1  four and a half LIM domains protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630

  5. XM_054326697.1 → XP_054182672.1  four and a half LIM domains protein 1 isoform X1

  6. XM_054326698.1 → XP_054182673.1  four and a half LIM domains protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B7Z5T4, B7Z793, O95212, Q13230, Q13642, Q13645, Q5JXI7, Q5M7Y6, Q6IB30, Q9NZ40, Q9UKZ8, Q9Y630
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13642.4 GenPept UniProtKB/Swiss-Prot:Q13642

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