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Aars2 alanyl-tRNA synthetase 2, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 224805, updated on 14-Nov-2024

Summary

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Official Symbol
Aars2provided by MGI
Official Full Name
alanyl-tRNA synthetase 2, mitochondrialprovided by MGI
Primary source
MGI:MGI:2681839
See related
Ensembl:ENSMUSG00000023938 AllianceGenome:MGI:2681839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm89; Aarsl; AlaRS
Summary
Predicted to enable alanine-tRNA ligase activity and aminoacyl-tRNA editing activity. Predicted to be involved in mitochondrial alanyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 8 and progressive leukoencephalopathy with ovarian failure. Orthologous to human AARS2 (alanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 20.6), ovary adult (RPKM 10.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Aars2 in Genome Data Viewer
Location:
17 B3; 17 22.51 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45817473..45831769)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45503515..45520843)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B230354K17 gene Neighboring gene STARR-positive B cell enhancer ABC_E5612 Neighboring gene STARR-seq mESC enhancer starr_42621 Neighboring gene spermatogenesis associated, serine-rich 1 Neighboring gene STARR-seq mESC enhancer starr_42624 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45625569-45626099 Neighboring gene STARR-seq mESC enhancer starr_42626 Neighboring gene STARR-positive B cell enhancer ABC_E4215 Neighboring gene STARR-positive B cell enhancer ABC_E9052 Neighboring gene t-complex-associated testis expressed 1 Neighboring gene transmembrane protein 151B Neighboring gene STARR-positive B cell enhancer ABC_E7533 Neighboring gene STARR-positive B cell enhancer ABC_E961 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:45695258-45695367 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria. Hilander T, et al. Nucleic Acids Res, 2018 Jan 25. PMID 29228266, Free PMC Article
  2. AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases. Li H, et al. Nature, 2024 Oct. PMID 39322678
  3. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
  4. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC69820

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables alanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables alanine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA editing activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide lactyltransferase (ATP-dependent) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in alanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial alanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial alanyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cGAS/STING signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alanine--tRNA ligase, mitochondrial
Names
alanyl-tRNA synthetase, mitochondrial
NP_001344929.1
NP_941010.2
XP_011244703.1
XP_017172929.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358000.2 → NP_001344929.1  alanine--tRNA ligase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163677
    Conserved Domains (1) summary
    PLN02900
    Location:19 → 618
    PLN02900; alanyl-tRNA synthetase

  2. NM_001431963.1 → NP_001418892.1  alanine--tRNA ligase, mitochondrial isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC163677

  3. NM_198608.3 → NP_941010.2  alanine--tRNA ligase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_941010.2

    Status: VALIDATED

    Source sequence(s)
    AC163677
    Consensus CDS
    CCDS28809.1
    UniProtKB/Swiss-Prot
    Q14CH7, Q68FH3, Q69ZM9
    Related
    ENSMUSP00000024733.8, ENSMUST00000024733.9
    Conserved Domains (4) summary
    smart00863
    Location:740 → 773
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    PLN02900
    Location:34 → 978
    PLN02900; alanyl-tRNA synthetase
    cd00673
    Location:37 → 275
    AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
    cl08469
    Location:549 → 651
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    45817473..45831769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317440.2 → XP_017172929.1  alanine--tRNA ligase, mitochondrial isoform X2

    Conserved Domains (1) summary
    PLN02900
    Location:19 → 618
    PLN02900; alanyl-tRNA synthetase

  2. XM_011246401.4 → XP_011244703.1  alanine--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PLN02900
    Location:7 → 641
    PLN02900; alanyl-tRNA synthetase

RNA

  1. XR_385317.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14CH7.1 GenPept UniProtKB/Swiss-Prot:Q14CH7

Gene LinkOut

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