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Tbc1d22a TBC1 domain family, member 22a [ Mus musculus (house mouse) ]

Gene ID: 223754, updated on 2-Nov-2024

Summary

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Official Symbol
Tbc1d22aprovided by MGI
Official Full Name
TBC1 domain family, member 22aprovided by MGI
Primary source
MGI:MGI:1289265
See related
Ensembl:ENSMUSG00000051864 AllianceGenome:MGI:1289265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D15Ertd781e
Summary
Predicted to enable 14-3-3 protein binding activity; GTPase activator activity; and protein homodimerization activity. Predicted to be active in Golgi apparatus. Orthologous to human TBC1D22A (TBC1 domain family member 22A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 17.9), thymus adult (RPKM 16.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tbc1d22a in Genome Data Viewer
Location:
15 E2; 15 40.56 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (86095502..86382704)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (86214411..86498503)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39412 Neighboring gene STARR-positive B cell enhancer ABC_E9422 Neighboring gene GRAM domain containing 4 Neighboring gene predicted gene 15722 Neighboring gene STARR-positive B cell enhancer mm9_chr15:86003680-86003981 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86012285-86012732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86013160-86013361 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86033071-86033180 Neighboring gene RIKEN cDNA 2810001A02 gene Neighboring gene ceramide kinase Neighboring gene STARR-positive B cell enhancer ABC_E7404 Neighboring gene STARR-seq mESC enhancer starr_39415 Neighboring gene predicted gene 15569 Neighboring gene predicted gene, 22818 Neighboring gene STARR-seq mESC enhancer starr_39416 Neighboring gene STARR-seq mESC enhancer starr_39418 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86165311-86165512 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:86216802-86216911 Neighboring gene STARR-seq mESC enhancer starr_39419 Neighboring gene predicted gene, 34965 Neighboring gene RIKEN cDNA 4930543I03 gene Neighboring gene predicted gene, 35118

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. van der Weyden L, et al. G3 (Bethesda), 2020 Jun 1. PMID 32245826, Free PMC Article
  2. Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death. Sellier C, et al. EMBO J, 2016 Jun 15. PMID 27103069, Free PMC Article
  3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28337

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables 14-3-3 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TBC1 domain family member 22A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358062.2 → NP_001344991.1  TBC1 domain family member 22A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115755, AC146911, AC163400
    Conserved Domains (1) summary
    pfam00566
    Location:50 → 240
    RabGAP-TBC; Rab-GTPase-TBC domain

  2. NM_001409162.1 → NP_001396091.1  TBC1 domain family member 22A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115755, AC116764, AC146911, AC163400

  3. NM_001409163.1 → NP_001396092.1  TBC1 domain family member 22A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC115755, AC116764, AC146911, AC163400

  4. NM_001409164.1 → NP_001396093.1  TBC1 domain family member 22A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC115755, AC116764, AC146911, AC163400

  5. NM_001409165.1 → NP_001396094.1  TBC1 domain family member 22A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC115755, AC116764, AC146911, AC163400

  6. NM_001409166.1 → NP_001396095.1  TBC1 domain family member 22A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC115755, AC116764, AC146911, AC163400

  7. NM_001409167.1 → NP_001396096.1  TBC1 domain family member 22A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115755, AC116764, AC146911, AC163400

  8. NM_145476.3 → NP_663451.2  TBC1 domain family member 22A isoform 1

    See identical proteins and their annotated locations for NP_663451.2

    Status: VALIDATED

    Source sequence(s)
    AC115755, AC116764, AC146911, AC163400
    Consensus CDS
    CCDS27729.1
    UniProtKB/Swiss-Prot
    Q3U268, Q3U3T0, Q8CA49, Q8R5A6
    Related
    ENSMUSP00000065721.9, ENSMUST00000063414.9
    Conserved Domains (1) summary
    smart00164
    Location:218 → 468
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    86095502..86382704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159365.1 → XP_036015258.1  TBC1 domain family member 22A isoform X1

    Conserved Domains (2) summary
    PRK10819
    Location:112 → 132
    PRK10819; transport protein TonB; Provisional
    pfam00566
    Location:278 → 468
    RabGAP-TBC; Rab-GTPase-TBC domain

  2. XM_036159366.1 → XP_036015259.1  TBC1 domain family member 22A isoform X2

    Conserved Domains (2) summary
    smart00164
    Location:218 → 442
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    PRK10819
    Location:112 → 132
    PRK10819; transport protein TonB; Provisional

  3. XM_036159367.1 → XP_036015260.1  TBC1 domain family member 22A isoform X3

    Conserved Domains (1) summary
    pfam00566
    Location:50 → 240
    RabGAP-TBC; Rab-GTPase-TBC domain

RNA

  1. XR_004938824.1 RNA Sequence

  2. XR_004938825.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R5A6.3 GenPept UniProtKB/Swiss-Prot:Q8R5A6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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