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Naprt nicotinate phosphoribosyltransferase [ Mus musculus (house mouse) ]

Gene ID: 223646, updated on 21-Aug-2024

Summary

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Official Symbol
Naprtprovided by MGI
Official Full Name
nicotinate phosphoribosyltransferaseprovided by MGI
Primary source
MGI:MGI:2442664
See related
Ensembl:ENSMUSG00000022574 AllianceGenome:MGI:2442664
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Naprt1; 9130210N20Rik
Summary
Predicted to enable nicotinate phosphoribosyltransferase activity. Predicted to be involved in NAD salvage and response to oxidative stress. Predicted to act upstream of or within pyridine nucleotide biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in alimentary system and liver. Orthologous to human NAPRT (nicotinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 179.7), small intestine adult (RPKM 113.2) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 35.05 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75762812..75766330, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75890963..75894481, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin D Neighboring gene STARR-seq mESC enhancer starr_39025 Neighboring gene maestro heat-like repeat family member 6 Neighboring gene eukaryotic translation elongation factor 1 delta Neighboring gene tigger transposable element derived 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities. Yaku K, et al. Nat Commun, 2021 Nov 19. PMID 34799586, Free PMC Article
  2. Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. Hara N, et al. J Biol Chem, 2007 Aug 24. PMID 17604275
  3. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases. Amici A, et al. Cell Chem Biol, 2017 May 18. PMID 28416276
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases
    Title: Synthesis and Degradation of Adenosine 5'-Tetraphosphate by Nicotinamide and Nicotinate Phosphoribosyltransferases.
  2. NA elevates cellular NAD levels through NAPRT function and, thus, protects the cells against stress, partly due to lack of feedback inhibition of NAPRT but not NamPRT by NAD
    Title: Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nicotinate phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate phosphoribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in NAD salvage IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nicotinate phosphoribosyltransferase
Names
NAPRTase
nicotinate phosphoribosyltransferase domain containing 1
nicotinate phosphoribosyltransferase domain-containing protein 1
NP_766195.2
XP_030104341.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172607.3 → NP_766195.2  nicotinate phosphoribosyltransferase

    See identical proteins and their annotated locations for NP_766195.2

    Status: PROVISIONAL

    Source sequence(s)
    AK033661
    Consensus CDS
    CCDS27552.1
    UniProtKB/Swiss-Prot
    Q8C7W2, Q8CC86
    Related
    ENSMUSP00000023237.7, ENSMUST00000023237.8
    Conserved Domains (2) summary
    PLN02885
    Location:13 → 525
    PLN02885; nicotinate phosphoribosyltransferase
    cd01570
    Location:15 → 398
    NAPRTase_A; Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75762812..75766330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248481.1 → XP_030104341.1  nicotinate phosphoribosyltransferase isoform X1

    Conserved Domains (1) summary
    PLN02885
    Location:2 → 358
    PLN02885; nicotinate phosphoribosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CC86.1 GenPept UniProtKB/Swiss-Prot:Q8CC86

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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