Ulk1 unc-51 like kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ulk1provided by MGI
Official Full Name: unc-51 like kinase 1provided by MGI
Primary source: MGI:MGI:1270126
See related: Ensembl:ENSMUSG00000029512 AllianceGenome:MGI:1270126
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Unc51.1; mKIAA0722
Summary: Enables Hsp90 protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in several processes, including macroautophagy; regulation of macromolecule biosynthetic process; and response to mitochondrial depolarisation. Acts upstream of or within several processes, including Ras protein signal transduction; generation of neurons; and radial glia guided migration of cerebellar granule cell. Located in several cellular components, including cytoplasmic vesicle membrane; neuronal cell body; and phagophore assembly site membrane. Part of Atg1/ULK1 kinase complex. Is expressed in several structures, including central nervous system; dorsal root ganglion; and retina. Orthologous to human ULK1 (unc-51 like autophagy activating kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 26.1), adrenal adult (RPKM 23.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 53.7 cM; 5 F

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (110932355..110957991, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (110784489..110810120, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FTO-mediated m [6]A demethylation of ULK1 mRNA promotes autophagy and activation of hepatic stellate cells in liver fibrosis.
Title: FTO-mediated m (6)A demethylation of ULK1 mRNA promotes autophagy and activation of hepatic stellate cells in liver fibrosis.
Ulk1 phosphorylation at S555 is not required for endurance training-induced improvements in exercise and metabolic capacity in mice.
Title: Ulk1 phosphorylation at S555 is not required for endurance training-induced improvements in exercise and metabolic capacity in mice.
Inhibition of ULK1/2 and KRAS[G12C] controls tumor growth in preclinical models of lung cancer.
Title: Inhibition of ULK1/2 and KRAS(G12C) controls tumor growth in preclinical models of lung cancer.
IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress.
Title: IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress.
DDIT3 deficiency accelerates bone remodeling during bone healing by enhancing osteoblast and osteoclast differentiation through ULK1-mediated autophagy.
Title: DDIT3 deficiency accelerates bone remodeling during bone healing by enhancing osteoblast and osteoclast differentiation through ULK1-mediated autophagy.
mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms.
Title: mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms.
Endurance Exercise Training Mitigates Diastolic Dysfunction in Diabetic Mice Independent of Phosphorylation of Ulk1 at S555.
Title: Endurance Exercise Training Mitigates Diastolic Dysfunction in Diabetic Mice Independent of Phosphorylation of Ulk1 at S555.
Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.
Title: Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response.
Exosomes of Adipose Tissue-Derived Stem Cells Promote Wound Healing by Sponging miR-17-5p and Inducing Autophagy Protein Ulk1.
Title: Exosomes of Adipose Tissue-Derived Stem Cells Promote Wound Healing by Sponging miR-17-5p and Inducing Autophagy Protein Ulk1.
Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity.
Title: Activation of eIF4E-binding-protein-1 rescues mTORC1-induced sarcopenia by expanding lysosomal degradation capacity.

Submit: New GeneRIF Correction See all GeneRIFs (90)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU041434 (e-PCR)
- UniSTS:159415

Ulk1 (e-PCR), detects polymorphism
- UniSTS:527598

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables Hsp90 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in axon extension	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid starvation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cerebellar granule cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collateral sprouting	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection regeneration	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within radial glia guided migration of cerebellar granule cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of macroautophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neurotrophin TRK receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein lipidation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein lipidation	ISO Inferred from Sequence Orthology more info
involved_in response to mitochondrial depolarisation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somatic sensory system development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Atg1/ULK1 kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Atg1/ULK1 kinase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of Atg1/ULK1 kinase complex	ISO Inferred from Sequence Orthology more info
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in omegasome membrane	ISO Inferred from Sequence Orthology more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site	ISO Inferred from Sequence Orthology more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site membrane	IDA Inferred from Direct Assay more info	PubMed
located_in phagophore assembly site membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase ULK1

Names: serine/threonine-protein kinase Unc51.1

NP_001334323.1

EC 2.7.11.1

NP_033495.2

EC 2.7.11.1

XP_006534915.1

EC 2.7.11.1

XP_011247721.1

EC 2.7.11.1

XP_011247722.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347394.1 → NP_001334323.1 serine/threonine-protein kinase ULK1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC121934, AC161348

Consensus CDS

CCDS84930.1

UniProtKB/TrEMBL

Q3UFT4, Q6PB82

Related

ENSMUSP00000143536.2, ENSMUST00000200299.2
NM_009469.3 → NP_033495.2 serine/threonine-protein kinase ULK1 isoform 2

See identical proteins and their annotated locations for NP_033495.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

BC057121

Consensus CDS

CCDS19532.1

UniProtKB/Swiss-Prot

O70405, Q6PGB2

UniProtKB/TrEMBL

A0A0R4J0B3, Q3U0V5, Q3U350

Related

ENSMUSP00000031490.7, ENSMUST00000031490.11

Conserved Domains (3) summary

smart00220
Location:16 → 278

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14202
Location:13 → 279

STKc_ULK1; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1

pfam12063
Location:838 → 1045

DUF3543; Domain of unknown function (DUF3543)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

110932355..110957991 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249420.4 → XP_011247722.1 serine/threonine-protein kinase ULK1 isoform X2

UniProtKB/Swiss-Prot

O70405, Q6PGB2

UniProtKB/TrEMBL

Q3U0V5, Q3U350

Conserved Domains (2) summary

pfam12063
Location:860 → 1067

DUF3543; Domain of unknown function (DUF3543)

cl21453
Location:13 → 301

PKc_like; Protein Kinases, catalytic domain
XM_011249419.4 → XP_011247721.1 serine/threonine-protein kinase ULK1 isoform X1

UniProtKB/TrEMBL

Q3UFT4

Conserved Domains (2) summary

pfam12063
Location:866 → 1073

DUF3543; Domain of unknown function (DUF3543)

cl21453
Location:13 → 301

PKc_like; Protein Kinases, catalytic domain
XM_006534852.4 → XP_006534915.1 serine/threonine-protein kinase ULK1 isoform X3

Conserved Domains (2) summary

pfam05109
Location:218 → 489

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam12063
Location:560 → 767

DUF3543; Domain of unknown function (DUF3543)