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FCGR2A Fc gamma receptor IIa [ Homo sapiens (human) ]

Gene ID: 2212, updated on 2-Nov-2024

Summary

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Official Symbol
FCGR2Aprovided by HGNC
Official Full Name
Fc gamma receptor IIaprovided by HGNC
Primary source
HGNC:HGNC:3616
See related
Ensembl:ENSG00000143226 MIM:146790; AllianceGenome:HGNC:3616
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD32; FCG2; FcGR; CD32A; CDw32; FCGR2; IGFR2; FCGR2A1; FcgammaRIIa
Summary
This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Expression
Broad expression in appendix (RPKM 39.7), placenta (RPKM 36.5) and 21 other tissues See more
Orthologs
all
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Genomic context

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See FCGR2A in Genome Data Viewer
Location:
1q23.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161505457..161524048)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160768080..160786676)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161475247..161489619)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tRNA-Gly (anticodon GCC) 4-1 Neighboring gene uncharacterized LOC105371473 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:161460810-161461039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1992 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9514 Neighboring gene tRNA-Asp (GTC) 10-1 Neighboring gene tRNA-Gly (anticodon GCC) 2-1 Neighboring gene heat shock protein family A (Hsp70) member 6 Neighboring gene tRNA-Leu (anticodon CAG) 1-6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD32 captures committed haemogenic endothelial cells during human embryonic development.
    Title: CD32 captures committed haemogenic endothelial cells during human embryonic development.
  2. Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration.
    Title: Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration.
  3. Genetic variation of FcgammaRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro.
    Title: Genetic variation of FcγRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro.
  4. New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes.
    Title: New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes.
  5. Platelet FcgammaRIIa expression in patients with stable coronary artery disease.
    Title: Platelet FcγRIIa expression in patients with stable coronary artery disease.
  6. Relationship Between Human FCgammaRIIA rs1801274 G Allele and Risk of Death Among Different SARS-CoV-2 Variants.
    Title: Relationship Between Human FCγRIIA rs1801274 G Allele and Risk of Death Among Different SARS-CoV-2 Variants.
  7. Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis.
    Title: Association between functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to rituximab in patients with autoimmune diseases: a meta-analysis.
  8. Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis.
    Title: Association between the functional FCGR3A F158V and FCGR2A R131H polymorphisms and responsiveness to biologics in rheumatoid arthritis patients: A meta-analysis.
  9. Comparative Analysis of FCGR Gene Polymorphism in Pulmonary Sarcoidosis and Tuberculosis.
    Title: Comparative Analysis of FCGR Gene Polymorphism in Pulmonary Sarcoidosis and Tuberculosis.
  10. Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease.
    Title: Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease.
Submit: New GeneRIF Correction See all GeneRIFs (353)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Cystic fibrosis
MedGen: C0010674 OMIM: 219700 GeneReviews: Cystic Fibrosis
not available
Malaria, susceptibility to
MedGen: C1970028 OMIM: 611162 GeneReviews: Not available
not available
Systemic lupus erythematosus
MedGen: C0024141 OMIM: 152700 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
EBI GWAS Catalog
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
EBI GWAS Catalog
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
EBI GWAS Catalog
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
EBI GWAS Catalog
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Identification of genetic loci associated with Helicobacter pylori serologic status.
EBI GWAS Catalog
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env IgG2 and IgG4 bind more poorly to enzymatically deglycosylated recombinant gp120 (rgp120) than to unchanged rgp120 PubMed
Nef nef HIV-1 Nef downregulates Fc-gamma Receptor II in human monocytes/macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC23887, MGC30032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables IgG binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IgG receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Fc-gamma receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in antibody-dependent cellular cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of tumor necrosis factor production IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in secretory granule membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
low affinity immunoglobulin gamma Fc region receptor II-a
Names
Fc fragment of IgG receptor IIa
Fc fragment of IgG, low affinity IIa, receptor (CD32)
Fc gamma receptor RIIa3
Immunoglobulin G Fc receptor II
fc-gamma-RIIa
fcRII-a
igG Fc receptor II-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012066.2 RefSeqGene

    Range
    5043..19415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1109

mRNA and Protein(s)

  1. NM_001136219.3 → NP_001129691.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor

    See identical proteins and their annotated locations for NP_001129691.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA634082, AK315225, AL590385
    Consensus CDS
    CCDS44264.1
    UniProtKB/Swiss-Prot
    P12318, Q8WUN1, Q8WW64
    UniProtKB/TrEMBL
    A0A346JF56
    Related
    ENSP00000271450.6, ENST00000271450.12
    Conserved Domains (3) summary
    cd05752
    Location:41 → 119
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:123 → 205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:129 → 205
    IG_like; Immunoglobulin like

  2. NM_001375296.1 → NP_001362225.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL590385, BC019931, BX379627
    Consensus CDS
    CCDS91088.1
    UniProtKB/TrEMBL
    A0A346JF56, A0A8V8TPS4
    Related
    ENSP00000514258.1, ENST00000699277.1
    Conserved Domains (2) summary
    cd05752
    Location:41 → 119
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:123 → 205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

  3. NM_001375297.1 → NP_001362226.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL590385
    UniProtKB/TrEMBL
    A0A346JF56
    Conserved Domains (2) summary
    cd05752
    Location:40 → 118
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:122 → 204
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

  4. NM_021642.5 → NP_067674.2  low affinity immunoglobulin gamma Fc region receptor II-a isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL590385, BC019931
    Consensus CDS
    CCDS30922.1
    UniProtKB/TrEMBL
    A0A346JF56
    Related
    ENSP00000356949.4, ENST00000367972.8
    Conserved Domains (3) summary
    cd05752
    Location:40 → 118
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:122 → 204
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:128 → 204
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161505457..161524048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000664.2 → XP_016856153.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

    UniProtKB/TrEMBL
    A0A346JF56

  2. XM_017000665.2 → XP_016856154.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

    UniProtKB/TrEMBL
    A0A346JF56

  3. XM_017000666.2 → XP_016856155.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X4

    UniProtKB/TrEMBL
    A0A346JF56
    Conserved Domains (3) summary
    cd05752
    Location:41 → 119
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:123 → 205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:129 → 205
    IG_like; Immunoglobulin like

  4. XM_047449441.1 → XP_047305397.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X1

  5. XM_017000663.3 → XP_016856152.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X2

    UniProtKB/TrEMBL
    A0A346JF56
    Conserved Domains (3) summary
    cd05752
    Location:40 → 118
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:122 → 204
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:128 → 204
    IG_like; Immunoglobulin like

  6. XM_011509290.3 → XP_011507592.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X5

    UniProtKB/TrEMBL
    A0A346JF56
    Conserved Domains (3) summary
    cd05752
    Location:41 → 119
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:123 → 205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:129 → 205
    IG_like; Immunoglobulin like

  7. XM_011509291.2 → XP_011507593.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X6

    Conserved Domains (3) summary
    cd05752
    Location:41 → 119
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    cd05753
    Location:123 → 205
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:129 → 205
    IG_like; Immunoglobulin like

  8. XM_024454040.2 → XP_024309808.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X7

    Conserved Domains (1) summary
    cd05753
    Location:1 → 66
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160768080..160786676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335134.1 → XP_054191109.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

  2. XM_054335135.1 → XP_054191110.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X3

  3. XM_054335136.1 → XP_054191111.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X4

  4. XM_054335132.1 → XP_054191107.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X1

  5. XM_054335133.1 → XP_054191108.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X2

  6. XM_054335137.1 → XP_054191112.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X5

  7. XM_054335138.1 → XP_054191113.1  low affinity immunoglobulin gamma Fc region receptor II-a isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12318.4 GenPept UniProtKB/Swiss-Prot:P12318

Gene LinkOut

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Chemical Information
Molecular Biology Databases
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