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Larp4b La ribonucleoprotein 4B [ Mus musculus (house mouse) ]

Gene ID: 217980, updated on 18-Sep-2024

Summary

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Official Symbol
Larp4bprovided by MGI
Official Full Name
La ribonucleoprotein 4Bprovided by MGI
Primary source
MGI:MGI:106330
See related
Ensembl:ENSMUSG00000033499 AllianceGenome:MGI:106330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Larp5; D13Wsu64e; A630096F19; A130023E24Rik
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in positive regulation of 3'-UTR-mediated mRNA stabilization and positive regulation of translation. Predicted to act upstream of or within regulation of translation. Predicted to be located in nucleolus and polysomal ribosome. Predicted to be active in cytoplasmic stress granule and cytosol. Is expressed in embryo; extraembryonic component; and vertebral axis musculature. Orthologous to human LARP4B (La ribonucleoprotein 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 5.9), liver E14 (RPKM 5.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Larp4b in Genome Data Viewer
Location:
13 A1; 13
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (9143643..9224487)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (9093653..9174451)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene GTP binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E2396 Neighboring gene predicted gene, 36264 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33610 Neighboring gene STARR-seq mESC enhancer starr_33614 Neighboring gene STARR-seq mESC enhancer starr_33615 Neighboring gene predicted gene 8784 Neighboring gene predicted gene, 46391

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function. Gehman LT, et al. Genes Dev, 2012 Mar 1. PMID 22357600, Free PMC Article
  2. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Cassar PA, et al. EMBO Rep, 2015 Oct. PMID 26265008, Free PMC Article
  3. Identification of differential protein interactors of lamin A and progerin. Kubben N, et al. Nucleus, 2010 Nov-Dec. PMID 21327095, Free PMC Article
  4. The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue. Martins-de-Souza D, et al. Proteomics Clin Appl, 2015 Oct. PMID 25921334
  5. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC78318

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
la-related protein 4B
Names
La ribonucleoprotein domain family, member 4B
La ribonucleoprotein domain family, member 5
la ribonucleoprotein domain family member 5
la-related protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311117.1 → NP_001298046.1  la-related protein 4B isoform 2

    See identical proteins and their annotated locations for NP_001298046.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC125484, AC131743, BC059218, BU056450, CF540574, CF950134
    Consensus CDS
    CCDS79162.1
    UniProtKB/Swiss-Prot
    Q6A0A2
    Related
    ENSMUSP00000089437.4, ENSMUST00000091829.4
    Conserved Domains (2) summary
    cd08036
    Location:159 → 233
    LARP_5; La RNA-binding domain of La-related protein 5
    cl17169
    Location:238 → 314
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_172585.3 → NP_766173.1  la-related protein 4B isoform 1

    See identical proteins and their annotated locations for NP_766173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC125484, AC131743, BC059218, BU056450, CF540574, CF950134
    Consensus CDS
    CCDS36588.1
    UniProtKB/Swiss-Prot
    Q3TUH7, Q6A0A2, Q6AZA8, Q8BJP3, Q8BY17
    Related
    ENSMUSP00000140993.2, ENSMUST00000188211.8
    Conserved Domains (2) summary
    cd08036
    Location:159 → 233
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:238 → 314
    RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    9143643..9224487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516476.4 → XP_006516539.1  la-related protein 4B isoform X3

    See identical proteins and their annotated locations for XP_006516539.1

    UniProtKB/Swiss-Prot
    Q3TUH7, Q6A0A2, Q6AZA8, Q8BJP3, Q8BY17
    Conserved Domains (2) summary
    cd08036
    Location:159 → 233
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:238 → 314
    RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

  2. XM_036157976.1 → XP_036013869.1  la-related protein 4B isoform X3

    UniProtKB/Swiss-Prot
    Q3TUH7, Q6A0A2, Q6AZA8, Q8BJP3, Q8BY17
    Conserved Domains (2) summary
    cd08036
    Location:159 → 233
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:238 → 314
    RRM_LARP5; RNA recognition motif (RRM) found in vertebrate La-related protein 5 (LARP5 or LARP4B)

  3. XM_011244254.4 → XP_011242556.1  la-related protein 4B isoform X2

    Conserved Domains (2) summary
    cd08036
    Location:1141 → 1215
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:1220 → 1296
    RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)

  4. XM_011244253.4 → XP_011242555.1  la-related protein 4B isoform X1

    Conserved Domains (2) summary
    cd08036
    Location:1141 → 1215
    LARP_5; La RNA-binding domain of La-related protein 5
    cd12706
    Location:1220 → 1296
    RRM_LARP5; RNA recognition motif in vertebrate La-related protein 5 (LARP5 or LARP4B)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002776.1: Suppressed sequence

    Description
    NM_001002776.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6A0A2.2 GenPept UniProtKB/Swiss-Prot:Q6A0A2

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