Chtf8 CTF8, chromosome transmission fidelity factor 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chtf8provided by MGI
Official Full Name: CTF8, chromosome transmission fidelity factor 8provided by MGI
Primary source: MGI:MGI:2443370
See related: Ensembl:ENSMUSG00000046691 AllianceGenome:MGI:2443370
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ctf8; Derpc; 5830457O10Rik
Summary: Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Predicted to be involved in positive regulation of DNA-directed DNA polymerase activity. Predicted to be located in nucleoplasm. Predicted to be part of Ctf18 RFC-like complex. Orthologous to several human genes including CHTF8 (chromosome transmission fidelity factor 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 35.1), CNS E11.5 (RPKM 29.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.3 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (107610495..107620225, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (106883863..106893593, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to DNA clamp loader activity	ISO Inferred from Sequence Orthology more info
contributes_to DNA clamp loader activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to single-stranded DNA helicase activity	ISO Inferred from Sequence Orthology more info
contributes_to single-stranded DNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-directed DNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Ctf18 RFC-like complex	ISO Inferred from Sequence Orthology more info
part_of Ctf18 RFC-like complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromosome transmission fidelity protein 8 homolog

Names: CTF8, chromosome transmission fidelity factor 8 homolog; chromosome transmission fidelity factor 8; protein DERPC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.