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Sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D [ Mus musculus (house mouse) ]

Gene ID: 214968, updated on 2-Nov-2024

Summary

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Official Symbol
Sema6dprovided by MGI
Official Full Name
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Dprovided by MGI
Primary source
MGI:MGI:2387661
See related
Ensembl:ENSMUSG00000027200 AllianceGenome:MGI:2387661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1479; D330011G23; 1110067B02Rik
Summary
Enables receptor ligand activity and semaphorin receptor binding activity. Involved in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and semaphorin-plexin signaling pathway. Acts upstream of or within negative regulation of smooth muscle cell migration; positive regulation of smooth muscle cell migration; and ventricular system development. Located in collagen-containing extracellular matrix. Is expressed in several structures, including central nervous system; gut mesenchyme; retina; spinal ganglion or nerve; and vascular element. Orthologous to human SEMA6D (semaphorin 6D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 11.2), lung adult (RPKM 8.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Sema6d in Genome Data Viewer
Location:
2 F1; 2 60.69 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (123931089..124509711)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (124089943..124667789)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05565 Neighboring gene predicted gene, 54147 Neighboring gene STARR-seq mESC enhancer starr_05566 Neighboring gene STARR-positive B cell enhancer mm9_chr2:123404999-123405300 Neighboring gene STARR-seq mESC enhancer starr_05568 Neighboring gene predicted gene, 39919 Neighboring gene STARR-seq mESC enhancer starr_05570 Neighboring gene RIKEN cDNA 4930517E11 gene Neighboring gene STARR-seq mESC enhancer starr_05571 Neighboring gene RIKEN cDNA 4930583P06 gene Neighboring gene STARR-seq mESC enhancer starr_05573 Neighboring gene STARR-seq mESC enhancer starr_05574 Neighboring gene STARR-seq mESC enhancer starr_05575 Neighboring gene STARR-seq mESC enhancer starr_05576 Neighboring gene STARR-positive B cell enhancer ABC_E5974 Neighboring gene predicted gene, 54148 Neighboring gene predicted gene, 34484 Neighboring gene predicted gene, 39920

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer. Hirai T, et al. JCI Insight, 2024 Feb 8. PMID 38329122, Free PMC Article
  2. Semaphorin 6D regulate corralling, hematoma compaction and white matter injury in mice after intracerebral hemorrhage. Sun T, et al. J Stroke Cerebrovasc Dis, 2022 Nov. PMID 36174325
  3. Semaphorin 6D regulates the late phase of CD4+ T cell primary immune responses. O'Connor BP, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18728195, Free PMC Article
  4. Characterization of a novel member of murine semaphorin family. Taniguchi M, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715272
  5. Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs. Nakanishi Y, et al. Neuron, 2024 Sep 4. PMID 39002542

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs.
    Title: Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs.
  2. Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer.
    Title: Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer.
  3. Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.
    Title: Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to Position and Target Retinal Ganglion Cell Axons.
  4. Semaphorin 6D regulate corralling, hematoma compaction and white matter injury in mice after intracerebral hemorrhage.
    Title: Semaphorin 6D regulate corralling, hematoma compaction and white matter injury in mice after intracerebral hemorrhage.
  5. Embryonic heart deletion of Sema6D significantly impaired the cardiac contraction of male adult hearts, while having a minor effect on female mutant hearts, suggesting that the effect of Sema6D-deletion in adult hearts is sex dependent.
    Title: SEMA6D regulates perinatal cardiomyocyte proliferation and maturation in mice.
  6. these findings highlight crucial roles for Sema6D reverse signaling in macrophage polarization, coupling immunity, and metabolism via PPARgamma.
    Title: Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization.
  7. Shear stress-regulated miR-27b promotes the interaction of endothelial cells with pericytes, partly by repressing SEMA6A and SEMA6D.
    Title: Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D.
  8. BMP-SEMA6D-Rho axis plays a key role in the initial stages of AV cushion mesenchyme formation.
    Title: Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice.
  9. Class 6 transmembrane semaphorins are unlikely to serve as major PlexA receptor ligands for the assembly of murine retinal circuit laminar organization.
    Title: Sema6B, Sema6C, and Sema6D expression and function during mammalian retinal development.
  10. These findings suggest a mechanism by which a complex of Sema6D, Nr-CAM, and Plexin-A1 at the chiasm midline alters the sign of Sema6D and signals Nr-CAM/Plexin-A1 receptors on retinal ganglion cells to implement the contralateral retinal cell projection.
    Title: Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropilin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of smooth muscle cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of smooth muscle cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in semaphorin-plexin signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of smooth muscle cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ventricular system development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ventricular system development ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
semaphorin-6D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290997.2 → NP_001277926.1  semaphorin-6D isoform Sema6D-2 precursor

    See identical proteins and their annotated locations for NP_001277926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (Sema6D-2) is shorter than isoform Sema6D-1. Both variants 2 and 3 encode isoform Sema6D-2.
    Source sequence(s)
    AL833808, AL928992, AL929570, AL935323
    Consensus CDS
    CCDS16671.1
    UniProtKB/Swiss-Prot
    Q76KF0
    Related
    ENSMUSP00000099531.2, ENSMUST00000103241.8
    Conserved Domains (3) summary
    PHA03247
    Location:834 → 981
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  2. NM_001291000.2 → NP_001277929.1  semaphorin-6D isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site and contains two additional in-frame exons in the central coding region, compared to variant 1. The encoded isoform (3) is longer than isoform Sema6D-1.
    Source sequence(s)
    AL929517, AL935323
    Consensus CDS
    CCDS71132.1
    UniProtKB/TrEMBL
    A2AW73
    Related
    ENSMUSP00000099530.3, ENSMUST00000103240.9
    Conserved Domains (3) summary
    PHA03247
    Location:905 → 1052
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  3. NM_001407285.1 → NP_001394214.1  semaphorin-6D isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AL929517, AL935323

  4. NM_172537.5 → NP_766125.2  semaphorin-6D isoform Sema6D-1 precursor

    See identical proteins and their annotated locations for NP_766125.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform Sema6D-1.
    Source sequence(s)
    AL929517, AL935323
    Consensus CDS
    CCDS16670.1
    UniProtKB/Swiss-Prot
    Q76KF0
    Related
    ENSMUSP00000061123.9, ENSMUST00000051419.15
    Conserved Domains (3) summary
    PHA03247
    Location:847 → 994
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 582
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  5. NM_199238.4 → NP_954708.1  semaphorin-6D isoform Sema6D-2 precursor

    See identical proteins and their annotated locations for NP_954708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (Sema6D-2) that is shorter than isoform Sema6D-1. Both variants 2 and 3 encode isoform Sema6D-2.
    Source sequence(s)
    AL929517, AL935323
    Consensus CDS
    CCDS16671.1
    UniProtKB/Swiss-Prot
    Q76KF0
    Related
    ENSMUSP00000075674.6, ENSMUST00000076335.12
    Conserved Domains (3) summary
    PHA03247
    Location:834 → 981
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  6. NM_199239.4 → NP_954709.1  semaphorin-6D isoform Sema6D-5 precursor

    See identical proteins and their annotated locations for NP_954709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an additional in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (Sema6D-5) that is longer than isoform Sema6D-1. The 5' UTR is incomplete because the evidence for this variant is for the CDS only, and multiple possible 5' UTR exon combinations exist.
    Source sequence(s)
    AL935323
    Consensus CDS
    CCDS38225.1
    UniProtKB/Swiss-Prot
    Q76KF0
    Related
    ENSMUSP00000077691.6, ENSMUST00000078621.12
    Conserved Domains (3) summary
    PHA03247
    Location:866 → 1013
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  7. NM_199240.4 → NP_954710.1  semaphorin-6D isoform Sema6D-6 precursor

    See identical proteins and their annotated locations for NP_954710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site and contains an additional in-frame exon in the central coding region, compared to variant 1. The encoded isoform (Sema6D-6) is longer than isoform Sema6D-1. The 5' UTR is incomplete because the evidence for this variant is for the CDS only, and multiple possible 5' UTR exon combinations exist.
    Source sequence(s)
    AL935323
    Consensus CDS
    CCDS16672.1
    UniProtKB/Swiss-Prot
    Q76KF0
    Related
    ENSMUSP00000099528.2, ENSMUST00000103238.2
    Conserved Domains (3) summary
    PHA03247
    Location:890 → 1037
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  8. NM_199241.4 → NP_954711.1  semaphorin-6D isoform Sema6D-4 precursor

    See identical proteins and their annotated locations for NP_954711.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site and contains two additional in-frame exons in the central coding region, compared to variant 1. The encoded isoform (Sema6D-4) is longer than isoform Sema6D-1. The 5' UTR is incomplete because the evidence for this variant is for the CDS only, and multiple possible 5' UTR exon combinations exist.
    Source sequence(s)
    AL935323
    Consensus CDS
    CCDS16673.1
    UniProtKB/Swiss-Prot
    A2AW72, Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0
    Conserved Domains (3) summary
    PHA03247
    Location:909 → 1056
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    123931089..124509711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249334.2 → XP_030105194.1  semaphorin-6D isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:922 → 1069
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  2. XM_036160315.1 → XP_036016208.1  semaphorin-6D isoform X7

    Conserved Domains (3) summary
    PHA03247
    Location:890 → 1037
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  3. XM_036160329.1 → XP_036016222.1  semaphorin-6D isoform X12

    Conserved Domains (3) summary
    PHA03247
    Location:834 → 981
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  4. XM_006499112.5 → XP_006499175.1  semaphorin-6D isoform X1

    See identical proteins and their annotated locations for XP_006499175.1

    Conserved Domains (3) summary
    PHA03247
    Location:922 → 1069
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  5. XM_036160290.1 → XP_036016183.1  semaphorin-6D isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:918 → 1065
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  6. XM_036160325.1 → XP_036016218.1  semaphorin-6D isoform X9

    Conserved Domains (3) summary
    PHA03247
    Location:866 → 1013
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  7. XM_036160303.1 → XP_036016196.1  semaphorin-6D isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:903 → 1050
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  8. XM_036160310.1 → XP_036016203.1  semaphorin-6D isoform X6

    Conserved Domains (3) summary
    PHA03247
    Location:899 → 1046
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  9. XM_030249369.2 → XP_030105229.1  semaphorin-6D isoform X11

    Conserved Domains (3) summary
    PHA03247
    Location:847 → 994
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 582
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  10. XM_036160291.1 → XP_036016184.1  semaphorin-6D isoform X3

    UniProtKB/Swiss-Prot
    A2AW72, Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0
    Conserved Domains (3) summary
    PHA03247
    Location:909 → 1056
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  11. XM_036160298.1 → XP_036016191.1  semaphorin-6D isoform X4

    UniProtKB/TrEMBL
    A2AW73
    Conserved Domains (3) summary
    PHA03247
    Location:905 → 1052
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  12. XM_036160326.1 → XP_036016219.1  semaphorin-6D isoform X10

    Conserved Domains (3) summary
    PHA03247
    Location:853 → 1000
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  13. XM_011239427.4 → XP_011237729.1  semaphorin-6D isoform X7

    See identical proteins and their annotated locations for XP_011237729.1

    UniProtKB/Swiss-Prot
    Q76KF0
    Conserved Domains (3) summary
    PHA03247
    Location:890 → 1037
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  14. XM_030249365.2 → XP_030105225.1  semaphorin-6D isoform X8

    Conserved Domains (3) summary
    PHA03247
    Location:886 → 1033
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  15. XM_030249372.2 → XP_030105232.1  semaphorin-6D isoform X12

    Conserved Domains (3) summary
    PHA03247
    Location:834 → 981
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  16. XM_036160336.1 → XP_036016229.1  semaphorin-6D isoform X18

    UniProtKB/TrEMBL
    Q8BKG8
    Conserved Domains (2) summary
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  17. XM_036160335.1 → XP_036016228.1  semaphorin-6D isoform X17

    UniProtKB/TrEMBL
    Q8BKG8
    Conserved Domains (2) summary
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  18. XM_036160331.1 → XP_036016224.1  semaphorin-6D isoform X13

    UniProtKB/TrEMBL
    Q8BKG8
    Conserved Domains (2) summary
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  19. XM_036160332.1 → XP_036016225.1  semaphorin-6D isoform X14

    UniProtKB/TrEMBL
    Q8BKG8
    Conserved Domains (2) summary
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  20. XM_036160333.1 → XP_036016226.1  semaphorin-6D isoform X15

    UniProtKB/TrEMBL
    Q8BKG8
    Conserved Domains (2) summary
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  21. XM_036160334.1 → XP_036016227.1  semaphorin-6D isoform X16

    UniProtKB/TrEMBL
    Q8BKG8
    Conserved Domains (2) summary
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  22. XM_036160337.1 → XP_036016230.1  semaphorin-6D isoform X19

    UniProtKB/TrEMBL
    Q8BKG8
    Conserved Domains (2) summary
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  23. XM_036160283.1 → XP_036016176.1  semaphorin-6D isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:922 → 1069
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  24. XM_036160288.1 → XP_036016181.1  semaphorin-6D isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:922 → 1069
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  25. XM_036160285.1 → XP_036016178.1  semaphorin-6D isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:922 → 1069
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  26. XM_006499113.5 → XP_006499176.1  semaphorin-6D isoform X1

    See identical proteins and their annotated locations for XP_006499176.1

    Conserved Domains (3) summary
    PHA03247
    Location:922 → 1069
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  27. XM_030249357.2 → XP_030105217.1  semaphorin-6D isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:903 → 1050
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  28. XM_030249371.2 → XP_030105231.1  semaphorin-6D isoform X11

    Conserved Domains (3) summary
    PHA03247
    Location:847 → 994
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 582
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  29. XM_030249343.2 → XP_030105203.1  semaphorin-6D isoform X3

    UniProtKB/Swiss-Prot
    A2AW72, Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0
    Conserved Domains (3) summary
    PHA03247
    Location:909 → 1056
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  30. XM_030249347.2 → XP_030105207.1  semaphorin-6D isoform X4

    UniProtKB/TrEMBL
    A2AW73
    Conserved Domains (3) summary
    PHA03247
    Location:905 → 1052
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  31. XM_030249368.2 → XP_030105228.1  semaphorin-6D isoform X10

    Conserved Domains (3) summary
    PHA03247
    Location:853 → 1000
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  32. XM_030249361.2 → XP_030105221.1  semaphorin-6D isoform X7

    Conserved Domains (3) summary
    PHA03247
    Location:890 → 1037
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  33. XM_030249366.2 → XP_030105226.1  semaphorin-6D isoform X8

    Conserved Domains (3) summary
    PHA03247
    Location:886 → 1033
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  34. XM_030249373.2 → XP_030105233.1  semaphorin-6D isoform X12

    Conserved Domains (3) summary
    PHA03247
    Location:834 → 981
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  35. XM_006499111.4 → XP_006499174.1  semaphorin-6D isoform X1

    See identical proteins and their annotated locations for XP_006499174.1

    Conserved Domains (3) summary
    PHA03247
    Location:922 → 1069
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  36. XM_017317001.2 → XP_017172490.1  semaphorin-6D isoform X3

    UniProtKB/Swiss-Prot
    A2AW72, Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0
    Related
    ENSMUSP00000099529.4, ENSMUST00000103239.10
    Conserved Domains (3) summary
    PHA03247
    Location:909 → 1056
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  37. XM_017317012.2 → XP_017172501.1  semaphorin-6D isoform X7

    UniProtKB/Swiss-Prot
    Q76KF0
    Related
    ENSMUSP00000077014.6, ENSMUST00000077847.12
    Conserved Domains (3) summary
    PHA03247
    Location:890 → 1037
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  38. XM_006499114.5 → XP_006499177.1  semaphorin-6D isoform X1

    See identical proteins and their annotated locations for XP_006499177.1

    Conserved Domains (3) summary
    PHA03247
    Location:922 → 1069
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 543
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  39. XM_030249345.2 → XP_030105205.1  semaphorin-6D isoform X3

    UniProtKB/Swiss-Prot
    A2AW72, Q76KF0, Q76KF1, Q76KF2, Q76KF3, Q76KF4, Q80TD0
    Conserved Domains (3) summary
    PHA03247
    Location:909 → 1056
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  40. XM_030249351.2 → XP_030105211.1  semaphorin-6D isoform X4

    UniProtKB/TrEMBL
    A2AW73
    Conserved Domains (3) summary
    PHA03247
    Location:905 → 1052
    PHA03247; large tegument protein UL36; Provisional
    pfam01437
    Location:514 → 569
    PSI; Plexin repeat
    cl15693
    Location:49 → 513
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76KF0.1 GenPept UniProtKB/Swiss-Prot:Q76KF0

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