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Lman2l lectin, mannose-binding 2-like [ Mus musculus (house mouse) ]

Gene ID: 214895, updated on 2-Nov-2024

Summary

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Official Symbol
Lman2lprovided by MGI
Official Full Name
lectin, mannose-binding 2-likeprovided by MGI
Primary source
MGI:MGI:2443010
See related
Ensembl:ENSMUSG00000001143 AllianceGenome:MGI:2443010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VIPL; VIP36-like; A630028F14Rik
Summary
Predicted to enable D-mannose binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and protein transport. Predicted to be located in Golgi apparatus. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and autosomal recessive intellectual developmental disorder 52. Orthologous to human LMAN2L (lectin, mannose binding 2 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 13.1), whole brain E14.5 (RPKM 9.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lman2l in Genome Data Viewer
Location:
1 B; 1 15.26 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36458274..36484352, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36418900..36445271, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2541 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36364755-36365011 Neighboring gene AT-rich interaction domain 5A Neighboring gene KAT8 regulatory NSL complex subunit 3 Neighboring gene microRNA 6898 Neighboring gene fer-1 like family member 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:36501343-36501452 Neighboring gene STARR-positive B cell enhancer ABC_E5746 Neighboring gene predicted gene, 33401 Neighboring gene predicted gene, 33454 Neighboring gene cyclin M4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp564L2423

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
VIP36-like protein
Names
LMAN2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013374.2 → NP_001013392.1  VIP36-like protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001013392.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) lacks an alternate in-frame exon compared to variant 1.
    Source sequence(s)
    AC084391, BC046969
    Consensus CDS
    CCDS14878.1
    UniProtKB/Swiss-Prot
    P59481, Q3TZ91
    Related
    ENSMUSP00000117200.2, ENSMUST00000125304.8
    Conserved Domains (1) summary
    cl14058
    Location:49 → 297
    lectin_L-type; legume lectins

  2. NM_001310517.1 → NP_001297446.1  VIP36-like protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001297446.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC084391, AK158015, BC046969, CB248466
    Consensus CDS
    CCDS78563.1
    UniProtKB/TrEMBL
    D3Z4P2
    Related
    ENSMUSP00000110663.2, ENSMUST00000115011.8
    Conserved Domains (1) summary
    cl14058
    Location:49 → 308
    lectin_L-type; legume lectins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    36458274..36484352 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252925.2 → XP_030108785.1  VIP36-like protein isoform X2

    Conserved Domains (1) summary
    cl14058
    Location:1 → 160
    lectin_L-type; legume lectins

  2. XM_006495854.5 → XP_006495917.1  VIP36-like protein isoform X1

    Conserved Domains (1) summary
    cl14058
    Location:1 → 171
    lectin_L-type; legume lectins

  3. XM_006495855.5 → XP_006495918.1  VIP36-like protein isoform X2

    Conserved Domains (1) summary
    cl14058
    Location:1 → 160
    lectin_L-type; legume lectins

  4. XM_017319753.3 → XP_017175242.1  VIP36-like protein isoform X1

    Conserved Domains (1) summary
    cl14058
    Location:1 → 171
    lectin_L-type; legume lectins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59481.1 GenPept UniProtKB/Swiss-Prot:P59481

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