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Fbxw10 F-box and WD-40 domain protein 10 [ Mus musculus (house mouse) ]

Gene ID: 213980, updated on 14-Nov-2024

Summary

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Official Symbol
Fbxw10provided by MGI
Official Full Name
F-box and WD-40 domain protein 10provided by MGI
Primary source
MGI:MGI:3052463
See related
Ensembl:ENSMUSG00000090173 AllianceGenome:MGI:3052463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HREP; Fbw10; SM25H2; SM2SH2
Summary
Orthologous to several human genes including FBXW10 (F-box and WD repeat domain containing 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 31.0) and thymus adult (RPKM 1.3) See more
Orthologs
human all
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Genomic context

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See Fbxw10 in Genome Data Viewer
Location:
11 B2; 11 38.78 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62737893..62768290)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62847067..62877464)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 286 Neighboring gene predicted gene, 24151 Neighboring gene tripartite motif-containing 16 Neighboring gene STARR-seq mESC enhancer starr_29718 Neighboring gene STARR-seq mESC enhancer starr_29719 Neighboring gene STARR-positive B cell enhancer ABC_E1826 Neighboring gene trans-golgi network vesicle protein 23B Neighboring gene trans-golgi network vesicle protein 23B, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice. Lin XT, et al. Cell Rep, 2023 Jul 25. PMID 37450367
  2. FBXW10 promotes hepatocarcinogenesis in male patients and mice. Luo YD, et al. Carcinogenesis, 2020 Jul 10. PMID 31400758
  3. FBXW10-S6K1 promotes ANXA2 polyubiquitination and KRAS activation to drive hepatocellular carcinoma development in males. Liu ZY, et al. Cancer Lett, 2023 Jul 10. PMID 37277019
  4. The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation. Carmona-Mora P, et al. Hum Genet, 2015 Oct. PMID 26275350
  5. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.
    Title: Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.
  2. FBXW10 promotes hepatocarcinogenesis in male patients and mice.
    Title: FBXW10 promotes hepatocarcinogenesis in male patients and mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
F-box/WD repeat-containing protein 10
Names
F-box and WD-40 domain-containing protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033669.3 → NP_001028841.2  F-box/WD repeat-containing protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645847
    Consensus CDS
    CCDS24833.2
    UniProtKB/TrEMBL
    B2RUM0, B7ZC91
    Related
    ENSMUSP00000117872.2, ENSMUST00000150989.8
    Conserved Domains (4) summary
    COG2319
    Location:434 → 657
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:423 → 687
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam00646
    Location:281 → 324
    F-box; F-box domain
    sd00039
    Location:462 → 498
    7WD40; WD40 repeat [structural motif]

  2. NM_001291441.2 → NP_001278370.1  F-box/WD repeat-containing protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645847
    Consensus CDS
    CCDS78968.1
    UniProtKB/TrEMBL
    B2RUM0, H3BLP9
    Related
    ENSMUSP00000135870.2, ENSMUST00000176577.2
    Conserved Domains (4) summary
    COG2319
    Location:434 → 657
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:423 → 657
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam00646
    Location:281 → 324
    F-box; F-box domain
    sd00039
    Location:462 → 498
    7WD40; WD40 repeat [structural motif]

  3. NM_001404775.1 → NP_001391704.1  F-box/WD repeat-containing protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645847

  4. NM_001404776.1 → NP_001391705.1  F-box/WD repeat-containing protein 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645847

  5. NM_001404777.1 → NP_001391706.1  F-box/WD repeat-containing protein 10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL645847

  6. NM_001404778.1 → NP_001391707.1  F-box/WD repeat-containing protein 10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL645847

RNA

  1. NR_175864.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL645847
    Related
    ENSMUST00000177336.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62737893..62768290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532782.2 → XP_006532845.1  F-box/WD repeat-containing protein 10 isoform X1

    UniProtKB/TrEMBL
    B2RUM0
    Conserved Domains (3) summary
    sd00039
    Location:436 → 469
    7WD40; WD40 repeat [structural motif]
    pfam00646
    Location:281 → 324
    F-box; F-box domain
    cl29593
    Location:418 → 620
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_001779946.2 RNA Sequence

  2. XR_001779947.2 RNA Sequence

  3. XR_879557.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SUS0.1 GenPept UniProtKB/Swiss-Prot:Q5SUS0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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