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STK32A serine/threonine kinase 32A [ Homo sapiens (human) ]

Gene ID: 202374, updated on 17-Jun-2024

Summary

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Official Symbol
STK32Aprovided by HGNC
Official Full Name
serine/threonine kinase 32Aprovided by HGNC
Primary source
HGNC:HGNC:28317
See related
Ensembl:ENSG00000169302 AllianceGenome:HGNC:28317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YANK1
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and peptidyl-serine phosphorylation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal (RPKM 5.1), thyroid (RPKM 4.8) and 21 other tissues See more
Orthologs
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Genomic context

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See STK32A in Genome Data Viewer
Location:
5q32
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (147235026..147401990)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (147770995..147937774)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (146614589..146767418)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2 regulatory subunit Bbeta Neighboring gene uncharacterized LOC105378214 Neighboring gene PPP2R2B intronic transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23362 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:146473503-146474702 Neighboring gene STK32A antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81891 Neighboring gene NANOG hESC enhancer GRCh37_chr5:146835510-146836011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16489 Neighboring gene dihydropyrimidinase like 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:146935385-146935884 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:146940356-146941285 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:146946379-146947278 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:146947279-146948178 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:146948179-146949078 Neighboring gene JAKMIP2 antisense RNA 1 Neighboring gene janus kinase and microtubule interacting protein 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:147051411-147052610 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:147101014-147101804 Neighboring gene uncharacterized LOC105378218

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The microRNA-130a-5p/RUNX2/STK32A network modulates tumor invasive and metastatic potential in non-small cell lung cancer. Ma F, et al. BMC Cancer, 2020 Jun 22. PMID 32571328, Free PMC Article
  2. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. Koskinen LL, et al. Tissue Antigens, 2009 Nov. PMID 19845895
  3. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
  4. The DNA sequence and comparative analysis of human chromosome 5. Schmutz J, et al. Nature, 2004 Sep 16. PMID 15372022
  5. Image-based genome-wide siRNA screen identifies selective autophagy factors. Orvedahl A, et al. Nature, 2011 Dec 1. PMID 22020285, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The microRNA-130a-5p/RUNX2/STK32A network modulates tumor invasive and metastatic potential in non-small cell lung cancer.
    Title: The microRNA-130a-5p/RUNX2/STK32A network modulates tumor invasive and metastatic potential in non-small cell lung cancer.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC22688

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 32A
Names
A930015B13Rik
CTB-108O6.2
yet another novel kinase 1
NP_001106195.1
NP_001274669.1
NP_659438.1
XP_011535878.1
XP_011535879.1
XP_011535881.1
XP_016864702.1
XP_016864703.1
XP_047272868.1
XP_054207986.1
XP_054207987.1
XP_054207988.1
XP_054207989.1
XP_054207990.1
XP_054207991.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112724.2 → NP_001106195.1  serine/threonine-protein kinase 32A isoform 1

    See identical proteins and their annotated locations for NP_001106195.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC009189, BC021666, DA110948, DA231845, DR006392, EB386256
    Consensus CDS
    CCDS47299.1
    UniProtKB/Swiss-Prot
    B3KSY0, Q8WU08
    UniProtKB/TrEMBL
    B4DR46
    Related
    ENSP00000381030.3, ENST00000397936.8
    Conserved Domains (2) summary
    smart00220
    Location:23 → 270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:22 → 281
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  2. NM_001287740.2 → NP_001274669.1  serine/threonine-protein kinase 32A isoform 3

    See identical proteins and their annotated locations for NP_001274669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC009189, AK315942
    Consensus CDS
    CCDS75351.1
    UniProtKB/TrEMBL
    B4DR46, B7Z9H7
    Related
    ENSP00000381535.3, ENST00000398523.3
    Conserved Domains (1) summary
    cd05578
    Location:22 → 281
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  3. NM_145001.4 → NP_659438.1  serine/threonine-protein kinase 32A isoform 2

    See identical proteins and their annotated locations for NP_659438.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AC009189, AC011338
    Consensus CDS
    CCDS54931.1
    UniProtKB/Swiss-Prot
    Q8WU08
    Related
    ENSP00000487441.1, ENST00000626951.2
    Conserved Domains (1) summary
    cl21453
    Location:22 → 157
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    147235026..147401990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537577.3 → XP_011535879.1  serine/threonine-protein kinase 32A isoform X2

    UniProtKB/TrEMBL
    B4DR46
    Conserved Domains (2) summary
    smart00220
    Location:23 → 270
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:22 → 281
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  2. XM_017009213.2 → XP_016864702.1  serine/threonine-protein kinase 32A isoform X3

    UniProtKB/TrEMBL
    A0A3B3IS85
    Related
    ENSP00000497167.1, ENST00000648628.1

  3. XM_011537579.3 → XP_011535881.1  serine/threonine-protein kinase 32A isoform X5

    See identical proteins and their annotated locations for XP_011535881.1

    Conserved Domains (2) summary
    smart00220
    Location:23 → 220
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:22 → 221
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  4. XM_047416912.1 → XP_047272868.1  serine/threonine-protein kinase 32A isoform X5

  5. XM_011537576.1 → XP_011535878.1  serine/threonine-protein kinase 32A isoform X1

    UniProtKB/TrEMBL
    B4DR46
    Conserved Domains (2) summary
    smart00220
    Location:21 → 268
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:20 → 279
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  6. XM_017009214.1 → XP_016864703.1  serine/threonine-protein kinase 32A isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    147770995..147937774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352012.1 → XP_054207987.1  serine/threonine-protein kinase 32A isoform X2

    UniProtKB/TrEMBL
    B4DR46

  2. XM_054352013.1 → XP_054207988.1  serine/threonine-protein kinase 32A isoform X3

    UniProtKB/TrEMBL
    A0A3B3IS85

  3. XM_054352015.1 → XP_054207990.1  serine/threonine-protein kinase 32A isoform X5

  4. XM_054352016.1 → XP_054207991.1  serine/threonine-protein kinase 32A isoform X5

  5. XM_054352011.1 → XP_054207986.1  serine/threonine-protein kinase 32A isoform X1

    UniProtKB/TrEMBL
    B4DR46

  6. XM_054352014.1 → XP_054207989.1  serine/threonine-protein kinase 32A isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WU08.2 GenPept UniProtKB/Swiss-Prot:Q8WU08

Gene LinkOut

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