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EIF5A eukaryotic translation initiation factor 5A [ Homo sapiens (human) ]

Gene ID: 1984, updated on 3-Nov-2024

Summary

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Official Symbol
EIF5Aprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 5Aprovided by HGNC
Primary source
HGNC:HGNC:3300
See related
Ensembl:ENSG00000132507 MIM:600187; AllianceGenome:HGNC:3300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FABAS; EIF-5A; EIF5A1; eIF-4D; eIF5AI
Summary
Enables U6 snRNA binding activity. Involved in several processes, including cellular response to virus; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and tumor necrosis factor-mediated signaling pathway. Located in annulate lamellae; cytoplasm; and nucleus. Part of nuclear pore. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in esophagus (RPKM 53.8), appendix (RPKM 49.4) and 25 other tissues See more
Orthologs
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Genomic context

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See EIF5A in Genome Data Viewer
Location:
17p13.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7306999..7312463)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7210983..7216447)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7210318..7215782)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Y-box binding protein 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7197310-7197485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8102 Neighboring gene uncharacterized LOC124903912 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11608 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:7209261-7210072 and GRCh37_chr17:7210073-7210883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8105 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8107 Neighboring gene G protein pathway suppressor 2 Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7226660-7227166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7227167-7227672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7231927-7232586 Neighboring gene Sharpr-MPRA regulatory region 1992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of eIF-5A in lung adenocarcinomas. Chen G, et al. Proteomics, 2003 Apr. PMID 12687616
  2. Renal Ischemia Tolerance Mediated by eIF5A Hypusination Inhibition Is Regulated by a Specific Modulation of the Endoplasmic Reticulum Stress. Melis N, et al. Cells, 2023 Jan 25. PMID 36766751, Free PMC Article
  3. Blocking eIF5A modification in cervical cancer cells alters the expression of cancer-related genes and suppresses cell proliferation. Mémin E, et al. Cancer Res, 2014 Jan 15. PMID 24220243, Free PMC Article
  4. Down-regulation of eIF5A-2 prevents epithelial-mesenchymal transition in non-small-cell lung cancer cells. Xu GD, et al. J Zhejiang Univ Sci B, 2013 Jun. PMID 23733422, Free PMC Article
  5. The role of acetylation in the subcellular localization of an oncogenic isoform of translation factor eIF5A. Ishfaq M, et al. Biosci Biotechnol Biochem, 2012. PMID 23132580

See all (241) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Insights into eukaryotic translation initiation factor 5A: Its role and mechanisms in protein synthesis.
    Title: Insights into eukaryotic translation initiation factor 5A: Its role and mechanisms in protein synthesis.
  2. Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene.
    Title: Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene.
  3. AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.
    Title: AMD1 promotes breast cancer aggressiveness via a spermidine-eIF5A hypusination-TCF4 axis.
  4. Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
    Title: Exosomal EIF5A derived from Lewis lung carcinoma induced adipocyte wasting in cancer cachexia.
  5. Targeted inhibition of eIF5A[hpu] suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
    Title: Targeted inhibition of eIF5A(hpu) suppresses tumor growth and polarization of M2-like tumor-associated macrophages in oral cancer.
  6. High levels of hypusinated eIF5A in leiomyoma and leiomyosarcoma pathologies: a possible novel therapeutic target.
    Title: High levels of hypusinated eIF5A in leiomyoma and leiomyosarcoma pathologies: a possible novel therapeutic target.
  7. Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
    Title: Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration.
  8. Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
    Title: Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
  9. Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability.
    Title: Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability.
  10. Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
    Title: Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
Submit: New GeneRIF Correction See all GeneRIFs (77)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Faundes-Banka syndrome
MedGen: C5543554 OMIM: 619376 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef downregulates the expression of eukaryotic translation initiation factor 5A (EIF5A) protein in Nef-transfected SupT1 cells PubMed
Rev rev eIF-5A binds Rev Response Element (RRE) RNA, an interaction likely to be involved in its association with Rev during nuclear export PubMed
rev eIF-5A directly interacts with CRM1 and mediates its binding to Rev, an effect that is required for nuclear export of Rev PubMed
rev eIF-5A is a hypusine-containing protein required for Rev-mediated nuclear export of HIV-1 mRNA PubMed
rev eIF-5A interacts with the ribosomal protein L5 during its Rev nuclear export activity PubMed
rev eIF-5A interacts with nucleoporins CAN/nup214, nup153, nup98, and nup62 as well as nuclear actin during the nuclear export of Rev PubMed
rev eIF-5A interacts with the activation domain of Rev (amino acids 75-83) PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation initiation factor 5A (EIF5A) at amino acid residues 5-6, 96-97, 97-98, and 100-101 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC99547, MGC104255

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U6 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of translational termination IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in annulate lamellae IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 5A-1
Names
eukaryotic initiation factor 5A
rev-binding factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143760.1 → NP_001137232.1  eukaryotic translation initiation factor 5A-1 isoform A

    See identical proteins and their annotated locations for NP_001137232.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) encodes the longer isoform (A).
    Source sequence(s)
    AC026954, AY129319
    Consensus CDS
    CCDS45601.1
    UniProtKB/TrEMBL
    I3L504
    Related
    ENSP00000336702.7, ENST00000336452.11
    Conserved Domains (1) summary
    cl28432
    Location:31 → 180
    PRK03999; translation initiation factor IF-5A; Provisional

  2. NM_001143761.1 → NP_001137233.1  eukaryotic translation initiation factor 5A-1 isoform B

    See identical proteins and their annotated locations for NP_001137233.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
    Source sequence(s)
    AC026954, AY129321
    Consensus CDS
    CCDS11099.1
    UniProtKB/Swiss-Prot
    A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
    UniProtKB/TrEMBL
    I3L397
    Related
    ENSP00000390677.2, ENST00000419711.6
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  3. NM_001143762.2 → NP_001137234.1  eukaryotic translation initiation factor 5A-1 isoform B

    See identical proteins and their annotated locations for NP_001137234.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (D) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
    Source sequence(s)
    AC026954, AY129322, BG479628
    Consensus CDS
    CCDS11099.1
    UniProtKB/Swiss-Prot
    A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
    UniProtKB/TrEMBL
    I3L397
    Related
    ENSP00000396073.2, ENST00000416016.2
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  4. NM_001370420.1 → NP_001357349.1  eukaryotic translation initiation factor 5A-1 isoform B

    Status: VALIDATED

    Source sequence(s)
    AC026954
    Consensus CDS
    CCDS11099.1
    UniProtKB/Swiss-Prot
    A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
    UniProtKB/TrEMBL
    I3L397
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  5. NM_001370421.1 → NP_001357350.1  eukaryotic translation initiation factor 5A-1 isoform B

    Status: VALIDATED

    Source sequence(s)
    AC026954
    Consensus CDS
    CCDS11099.1
    UniProtKB/Swiss-Prot
    A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
    UniProtKB/TrEMBL
    I3L397
    Related
    ENSP00000460284.1, ENST00000573714.5
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

  6. NM_001970.5 → NP_001961.1  eukaryotic translation initiation factor 5A-1 isoform B

    See identical proteins and their annotated locations for NP_001961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant A. The encoded isoform (B) has a shorter N-terminus compared to isoform A. Variants B, C, and D encode the same isoform.
    Source sequence(s)
    AC026954, AY129320, CB111036
    Consensus CDS
    CCDS11099.1
    UniProtKB/Swiss-Prot
    A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2
    UniProtKB/TrEMBL
    I3L397
    Related
    ENSP00000336776.8, ENST00000336458.13
    Conserved Domains (1) summary
    cl30809
    Location:1 → 150
    PLN03107; eukaryotic translation initiation factor 5A; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7306999..7312463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024301.3 → XP_016879790.1  eukaryotic translation initiation factor 5A-1 isoform X1

    UniProtKB/TrEMBL
    B7Z8F1

  2. XM_047435523.1 → XP_047291479.1  eukaryotic translation initiation factor 5A-1 isoform X1

  3. XM_011523710.3 → XP_011522012.1  eukaryotic translation initiation factor 5A-1 isoform X1

    See identical proteins and their annotated locations for XP_011522012.1

    UniProtKB/TrEMBL
    B7Z8F1

  4. XM_011523712.4 → XP_011522014.1  eukaryotic translation initiation factor 5A-1 isoform X1

    See identical proteins and their annotated locations for XP_011522014.1

    UniProtKB/TrEMBL
    B7Z8F1

  5. XM_011523711.3 → XP_011522013.1  eukaryotic translation initiation factor 5A-1 isoform X1

    See identical proteins and their annotated locations for XP_011522013.1

    UniProtKB/TrEMBL
    B7Z8F1

  6. XM_047435524.1 → XP_047291480.1  eukaryotic translation initiation factor 5A-1 isoform X2

    UniProtKB/Swiss-Prot
    A8K9A0, D3DTP2, P10159, P63241, Q16182, Q7L7L3, Q7Z4L1, Q9D0G2

  7. XM_011523713.3 → XP_011522015.1  eukaryotic translation initiation factor 5A-1 isoform X1

    See identical proteins and their annotated locations for XP_011522015.1

    UniProtKB/TrEMBL
    B7Z8F1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160020.1 Reference GRCh38.p14 PATCHES

    Range
    65364..70828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332651.1 → XP_054188626.1  eukaryotic translation initiation factor 5A-1 isoform X1

  2. XM_054332647.1 → XP_054188622.1  eukaryotic translation initiation factor 5A-1 isoform X1

  3. XM_054332648.1 → XP_054188623.1  eukaryotic translation initiation factor 5A-1 isoform X1

  4. XM_054332649.1 → XP_054188624.1  eukaryotic translation initiation factor 5A-1 isoform X1

  5. XM_054332652.1 → XP_054188627.1  eukaryotic translation initiation factor 5A-1 isoform X1

  6. XM_054332650.1 → XP_054188625.1  eukaryotic translation initiation factor 5A-1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7210983..7216447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315317.1 → XP_054171292.1  eukaryotic translation initiation factor 5A-1 isoform X1

  2. XM_054315313.1 → XP_054171288.1  eukaryotic translation initiation factor 5A-1 isoform X1

  3. XM_054315314.1 → XP_054171289.1  eukaryotic translation initiation factor 5A-1 isoform X1

  4. XM_054315315.1 → XP_054171290.1  eukaryotic translation initiation factor 5A-1 isoform X1

  5. XM_054315318.1 → XP_054171293.1  eukaryotic translation initiation factor 5A-1 isoform X1

  6. XM_054315316.1 → XP_054171291.1  eukaryotic translation initiation factor 5A-1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63241.2 GenPept UniProtKB/Swiss-Prot:P63241

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