Ralbp1 ralA binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ralbp1provided by MGI
Official Full Name: ralA binding protein 1provided by MGI
Primary source: MGI:MGI:108466
See related: Ensembl:ENSMUSG00000024096 AllianceGenome:MGI:108466
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rip1; RLIP76
Summary: Enables GTPase activator activity and small GTPase binding activity. Involved in positive regulation of GTPase activity. Predicted to be located in mitochondrion; nuclear body; and plasma membrane. Predicted to be active in Schaffer collateral - CA1 synapse and membrane. Used to study microphthalmia. Human ortholog(s) of this gene implicated in pancreatic adenocarcinoma. Orthologous to human RALBP1 (ralA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 25.5), lung adult (RPKM 22.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E1.1; 17 35.26 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (66155410..66192750, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (65848415..65885755, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS.
Title: Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS.
RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease.
Title: RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease.
Rlip deficiency suppresses spontaneous malignancy in p53(-/-) mice.
Title: Rlip depletion prevents spontaneous neoplasia in TP53 null mice.
The results show that ARNO interaction with the RLIP76 N-terminus regulates cell spreading and motility via PI3K and Arf6, independent of RLIP76 control of Rac.
Title: The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration.
RLIP76 acts as a scaffold at recycling endosomes by binding activated R-Ras, recruiting ARNO to activate Arf6, thereby contributing to cell spreading and migration.
Title: RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.
The expression of Hsf4b known to be involved in lens development is down regulated in the lens of these Tg mice.
Title: Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia.
a fundamental role of RLIP76 in regulating the function of obesity-promoting pro-inflammatory cytokines
Title: RLIP76 protein knockdown attenuates obesity due to a high-fat diet.
RalBP1 is a gene regulating the seizure threshold and synaptic inhibition in mice
Title: Down-regulation of RalBP1 expression reduces seizure threshold and synaptic inhibition in mice.
results establish that RLIP76 is required for efficient endothelial cell function and angiogenesis in solid tumors
Title: RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization.
RLIP76 represents a mechanistically significant target for developing effective interventions in aggressive and refractory pancreatic cancers
Title: RLIP76 regulates PI3K/Akt signaling and chemo-radiotherapy resistance in pancreatic cancer.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MTH564 (e-PCR)
- UniSTS:128032

D17Mit217.3 (e-PCR), detects polymorphism
- UniSTS:128033

RH125071 (e-PCR)
- UniSTS:161893

X80937 (e-PCR)
- UniSTS:125864

Rip1 (e-PCR), detects polymorphism
- UniSTS:144351

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type glutathione S-conjugate transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in doxorubicin transport	IEA Inferred from Electronic Annotation more info
involved_in doxorubicin transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Cdc42 protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ralA-binding protein 1

Names: DNP-SG ATPase; Ral-interacting protein 1; dinitrophenyl S-glutathione ATPase

NP_001185878.1

EC 7.6.2.2

EC 7.6.2.3

NP_033093.2

EC 7.6.2.2

EC 7.6.2.3

XP_006523978.1

EC 7.6.2.2

EC 7.6.2.3

XP_036016315.1

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198949.1 → NP_001185878.1 ralA-binding protein 1

See identical proteins and their annotated locations for NP_001185878.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC067073, CJ146118

Consensus CDS

CCDS37678.1

UniProtKB/Swiss-Prot

Q62172, Q6NXH5, Q9CRE5

UniProtKB/TrEMBL

Q3TX60

Related

ENSMUSP00000024905.10, ENSMUST00000024905.11

Conserved Domains (1) summary

cd04381
Location:190 → 371

RhoGap_RalBP1; RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 ...
NM_009067.5 → NP_033093.2 ralA-binding protein 1

See identical proteins and their annotated locations for NP_033093.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC067073, CK627599

Consensus CDS

CCDS37678.1

UniProtKB/Swiss-Prot

Q62172, Q6NXH5, Q9CRE5

UniProtKB/TrEMBL

Q3TX60

Related

ENSMUSP00000129448.3, ENSMUST00000166543.10

Conserved Domains (1) summary

cd04381
Location:190 → 371

RhoGap_RalBP1; RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

66155410..66192750 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523915.4 → XP_006523978.1 ralA-binding protein 1 isoform X1

UniProtKB/TrEMBL

Q3TX60

Conserved Domains (2) summary

COG1196
Location:399 → 556

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd04381
Location:190 → 371

RhoGap_RalBP1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently ...
XM_036160422.1 → XP_036016315.1 ralA-binding protein 1 isoform X2

Conserved Domains (1) summary

cd04381
Location:190 → 371

RhoGap_RalBP1; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently ...