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EIF4B eukaryotic translation initiation factor 4B [ Homo sapiens (human) ]

Gene ID: 1975, updated on 17-Nov-2024

Summary

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Official Symbol
EIF4Bprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 4Bprovided by HGNC
Primary source
HGNC:HGNC:3285
See related
Ensembl:ENSG00000063046 MIM:603928; AllianceGenome:HGNC:3285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF-4B; PRO1843
Summary
Enables RNA binding activity. Predicted to be involved in regulation of translational initiation. Located in cytosol. Biomarker of autism spectrum disorder and major depressive disorder. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary (RPKM 285.6), thyroid (RPKM 146.6) and 25 other tissues See more
Orthologs
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Genomic context

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See EIF4B in Genome Data Viewer
Location:
12q13.13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53006456..53042215)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52970957..53006612)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53400240..53435999)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53292699-53293198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53295217-53296061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4486 Neighboring gene microRNA 9898 Neighboring gene keratin 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53311823-53312324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:53312325-53312824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53337539-53338133 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:53339323-53339918 Neighboring gene Sharpr-MPRA regulatory region 15494 Neighboring gene KRT18 locus control region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53358683-53359326 Neighboring gene keratin 18 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53365007-53365934 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53365935-53366860 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:53397033-53397195 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53399611-53400354 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53400355-53401098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6401 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53441165-53442009 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53442010-53442853 Neighboring gene TNS2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6402 Neighboring gene tensin 2 Neighboring gene microRNA 6757

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Eukaryotic initiation factor 4B is a multi-functional RNA binding protein that regulates histone mRNAs.
    Title: Eukaryotic initiation factor 4B is a multi-functional RNA binding protein that regulates histone mRNAs.
  2. Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study.
    Title: Genetic evidence supporting potential causal roles of EIF4 family in breast cancer: a two-sample randomized Mendelian study.
  3. Backbone resonance assignments of the C-terminal region of human translation initiation factor eIF4B.
    Title: Backbone resonance assignments of the C-terminal region of human translation initiation factor eIF4B.
  4. DOCK3-Associated Neurodevelopmental Disorder-Clinical Features and Molecular Basis.
    Title: DOCK3-Associated Neurodevelopmental Disorder-Clinical Features and Molecular Basis.
  5. CDKN2AIP-induced cell senescence and apoptosis of testicular seminoma are associated with CARM1 and eIF4beta.
    Title: CDKN2AIP-induced cell senescence and apoptosis of testicular seminoma are associated with CARM1 and eIF4β.
  6. eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma.
    Title: eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma.
  7. Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B.
    Title: Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B.
  8. eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated amyotrophic lateral sclerosis.
    Title: eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS.
  9. High EIF4B expression is associated with Malignant Grade in Prostate Cancer.
    Title: Pim-2 Cooperates with Downstream Factor XIAP to Inhibit Apoptosis and Intensify Malignant Grade in Prostate Cancer.
  10. FASN-induced S6 kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in diffuse large B-cell lymphoma.
    Title: Fatty Acid Synthase induced S6Kinase facilitates USP11-eIF4B complex formation for sustained oncogenic translation in DLBCL.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies new prostate cancer susceptibility loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated eukaryotic translation initiation factor 4B (EIF4B) protein is incorporated into HIV-1 Gag virus-like particles PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA strand annealing activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA strand-exchange activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosomal small subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in eukaryotic translation initiation factor 4F complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translational initiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic translation initiation factor 4F complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300821.3 → NP_001287750.1  eukaryotic translation initiation factor 4B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC068888
    Consensus CDS
    CCDS73474.1
    UniProtKB/TrEMBL
    B4DRM3, E7EX17
    Related
    ENSP00000388806.3, ENST00000420463.7
    Conserved Domains (2) summary
    COG0724
    Location:83 → 190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12402
    Location:95 → 171
    RRM_eIF4B; RNA recognition motif in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

  2. NM_001330654.2 → NP_001317583.1  eukaryotic translation initiation factor 4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC068888
    Consensus CDS
    CCDS86303.1
    UniProtKB/TrEMBL
    B4DRM3
    Related
    ENSP00000412530.3, ENST00000416762.7

  3. NM_001417.7 → NP_001408.2  eukaryotic translation initiation factor 4B isoform 2

    See identical proteins and their annotated locations for NP_001408.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC068888
    Consensus CDS
    CCDS41788.1
    UniProtKB/Swiss-Prot
    B4DS13, P23588, Q4G0E3, Q53HQ2, Q6GPH5, Q6IB46, Q8WYK5
    UniProtKB/TrEMBL
    B4DRM3
    Related
    ENSP00000262056.9, ENST00000262056.14
    Conserved Domains (3) summary
    PRK12678
    Location:158 → 273
    PRK12678; transcription termination factor Rho; Provisional
    PTZ00108
    Location:372 → 608
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    cd12402
    Location:94 → 175
    RRM_eIF4B; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 4B (eIF-4B) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    53006456..53042215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    52970957..53006612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018507.1: Suppressed sequence

    Description
    NM_018507.1: This RefSeq was permanently suppressed because it is primarily 3'' UTR sequence and it is on the wrong strand compared to other mRNA transcripts for the gene.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23588.2 GenPept UniProtKB/Swiss-Prot:P23588

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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