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Ppp1cb protein phosphatase 1 catalytic subunit beta [ Mus musculus (house mouse) ]

Gene ID: 19046, updated on 2-Nov-2024

Summary

Official Symbol
Ppp1cbprovided by MGI
Official Full Name
protein phosphatase 1 catalytic subunit betaprovided by MGI
Primary source
MGI:MGI:104871
See related
Ensembl:ENSMUSG00000014956 AllianceGenome:MGI:104871
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200010B19
Summary
Enables protein serine/threonine phosphatase activity. Involved in circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and protein dephosphorylation. Located in cytoplasm. Is expressed in eye; limb; and telencephalon. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 116.5), liver E14 (RPKM 43.7) and 17 other tissues See more
Orthologs
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Genomic context

See Ppp1cb in Genome Data Viewer
Location:
5 17.33 cM; 5 B1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (32616192..32651057)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (32458848..32493713)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phospholipase B1 Neighboring gene predicted gene, 36840 Neighboring gene STARR-seq mESC enhancer starr_12791 Neighboring gene STARR-seq mESC enhancer starr_12792 Neighboring gene STARR-seq mESC enhancer starr_12794 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12795 Neighboring gene predicted gene 15614 Neighboring gene STARR-seq mESC enhancer starr_12798 Neighboring gene methyltransferase-like protein 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12799 Neighboring gene STARR-positive B cell enhancer ABC_E8048 Neighboring gene predicted gene 10461 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables myosin-light-chain-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables myosin-light-chain-phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex ISO
Inferred from Sequence Orthology
more info
 
part_of PTW/PP1 phosphatase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in glycogen granule ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein phosphatase type 1 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein phosphatase PP1-beta catalytic subunit
Names
PP-1B
NP_766295.2
XP_006503843.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172707.3NP_766295.2  serine/threonine-protein phosphatase PP1-beta catalytic subunit

    See identical proteins and their annotated locations for NP_766295.2

    Status: VALIDATED

    Source sequence(s)
    AC102372, AK017392, AK160743, AK166623
    Consensus CDS
    CCDS19193.1
    UniProtKB/Swiss-Prot
    P62141, Q3TBE5, Q3TL90, Q542E7, Q8C285, Q9DBY2
    UniProtKB/TrEMBL
    Q3U7K1
    Related
    ENSMUSP00000015100.9, ENSMUST00000015100.15
    Conserved Domains (1) summary
    cd07414
    Location:7297
    MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    32616192..32651057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503780.2XP_006503843.1  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1

    Conserved Domains (1) summary
    cl13995
    Location:7197
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain