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agt-1 Methylated-DNA--protein-cysteine methyltransferase [ Caenorhabditis elegans ]

Gene ID: 190454, updated on 18-Sep-2024

Summary

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Official Symbol
agt-1
Official Full Name
Methylated-DNA--protein-cysteine methyltransferase
Primary source
WormBase:WBGene00000093
Locus tag
CELE_Y62E10A.5
See related
AllianceGenome:WB:WBGene00000093
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables damaged DNA binding activity and transferase activity, transferring alkyl or aryl (other than methyl) groups. Involved in DNA dealkylation involved in DNA repair. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; nervous system cancer (multiple); and urinary bladder cancer. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See agt-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (13368276..13369412, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein;Serpentine Receptor, class SX Neighboring gene Large ribosomal subunit protein P2 Neighboring gene Ribonuclease P protein subunit p20 Neighboring gene Protein kish

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel DNA repair alkyltransferase from Caenorhabditis elegans. Kanugula S, et al. Environ Mol Mutagen, 2001. PMID 11746760
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring alkyl or aryl (other than methyl) groups IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA alkylation repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
Methylated-DNA--protein-cysteine methyltransferase
NP_001041054.1
  • Confirmed by transcript evidence
NP_001041055.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    13368276..13369412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047589.3 → NP_001041054.1  Methylated-DNA--protein-cysteine methyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041054.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1Y0
    Conserved Domains (1) summary
    pfam01035
    Location:88 → 168
    DNA_binding_1; 6-O-methylguanine DNA methyltransferase, DNA binding domain

  2. NM_001047590.4 → NP_001041055.1  Methylated-DNA--protein-cysteine methyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041055.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2HQK2
    Conserved Domains (1) summary
    pfam01035
    Location:46 → 126
    DNA_binding_1; 6-O-methylguanine DNA methyltransferase, DNA binding domain
Nucleotide Protein
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