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bcas-2 Pre-mRNA-splicing factor SPF27 [ Caenorhabditis elegans ]

Gene ID: 188435, updated on 2-Nov-2024

Summary

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Official Symbol
bcas-2
Official Full Name
Pre-mRNA-splicing factor SPF27
Primary source
WormBase:WBGene00020441
Locus tag
CELE_T12A2.7
See related
AllianceGenome:WB:WBGene00020441
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in mRNA processing. Predicted to be located in nucleus. Predicted to be part of Prp19 complex and catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See bcas-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (6244672..6245828, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene TPX2 domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene GEN1 Holliday junction resolvase homolog Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pre-mRNA-splicing factor SPF27
NP_498360.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    6244672..6245828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065959.8 → NP_498360.2  Pre-mRNA-splicing factor SPF27 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_498360.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22417
    Conserved Domains (1) summary
    pfam05700
    Location:23 → 224
    BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)
Nucleotide Protein
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