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gpx-1 Glutathione peroxidase 1 [ Caenorhabditis elegans ]

Gene ID: 184981, updated on 18-Sep-2024

Summary

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Official Symbol
gpx-1
Official Full Name
Glutathione peroxidase 1
Primary source
WormBase:WBGene00009165
Locus tag
CELE_F26E4.12
See related
AllianceGenome:WB:WBGene00009165
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables phospholipid-hydroperoxide glutathione peroxidase activity. Involved in regulation of peptide transport. Predicted to be located in cytoplasm. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See gpx-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (9780349..9781413)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene FAS1 domain-containing protein Neighboring gene ncRNA Neighboring gene Ribonuclease 3 Neighboring gene ncRNA Neighboring gene Tubulin alpha chain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging in Caenorhabditis elegans. Sakamoto T, et al. Genes Cells, 2014 Oct. PMID 25200408
  2. A glutathione peroxidase, intracellular peptidases and the TOR complexes regulate peptide transporter PEPT-1 in C. elegans. Benner J, et al. PLoS One, 2011. PMID 21980510, Free PMC Article
  3. The Redox System in C. elegans, a Phylogenetic Approach. Johnston AD, et al. J Toxicol, 2012. PMID 22899914, Free PMC Article
  4. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. Lewis JA, et al. BMC Genomics, 2009 Apr 29. PMID 19402892, Free PMC Article
  5. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid-hydroperoxide glutathione peroxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response HEP PubMed 
involved_in regulation of peptide transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to chemical IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Glutathione peroxidase 1
NP_492598.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    9780349..9781413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060197.3 → NP_492598.1  Glutathione peroxidase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492598.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O02621
    Conserved Domains (1) summary
    cd00340
    Location:3 → 155
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O02621.1

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