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crls-1 putative cardiolipin synthase (CMP-forming) [ Caenorhabditis elegans ]

Gene ID: 184910, updated on 2-Nov-2024

Summary

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Official Symbol
crls-1
Official Full Name
putative cardiolipin synthase (CMP-forming)
Primary source
WormBase:WBGene00017763
Locus tag
CELE_F23H11.9
See related
AllianceGenome:WB:WBGene00017763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cardiolipin synthase (CMP-forming). Involved in cardiolipin biosynthetic process; regulation of cell population proliferation; and regulation of mitochondrial membrane potential. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 57. Orthologous to human CRLS1 (cardiolipin synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See crls-1 in Genome Data Viewer
Location:
chromosome: III
Exon count:
4
Sequence:
Chromosome: III; NC_003281.10 (908330..909902, complement)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene TATA box-binding protein-associated factor RNA polymerase I subunit B Neighboring gene Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Neighboring gene Rho-GAP domain-containing protein Neighboring gene Deltamethrin resistance protein prag01 domain-containing protein Neighboring gene MYND-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease. Wang S, et al. PLoS One, 2016. PMID 27736935, Free PMC Article
  2. Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology. Matsumura A, et al. FEBS Lett, 2018 Jan. PMID 29251771
  3. Deficiency of cardiolipin synthase causes abnormal mitochondrial function and morphology in germ cells of Caenorhabditis elegans. Sakamoto T, et al. J Biol Chem, 2012 Feb 10. PMID 22174409, Free PMC Article
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables cardiolipin synthase (CMP-forming) IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cardiolipin synthase (CMP-forming) IEA
Inferred from Electronic Annotation
more info
  
enables cardiolipin synthase (CMP-forming) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cardiolipin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiolipin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
putative cardiolipin synthase (CMP-forming)
NP_001022547.1
  • Confirmed by transcript evidence
NP_001379893.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    908330..909902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393270.1 → NP_001379893.1  putative cardiolipin synthase (CMP-forming) [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01916, Q5F4V9
    Conserved Domains (1) summary
    PLN02794
    Location:56 → 209
    PLN02794; cardiolipin synthase

  2. NM_001027376.6 → NP_001022547.1  putative cardiolipin synthase (CMP-forming) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001022547.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01916
    Conserved Domains (1) summary
    cl00453
    Location:32 → 215
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01916.1

Gene LinkOut

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