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ckb-4 Choline/ethanolamine kinase [ Caenorhabditis elegans ]

Gene ID: 184864, updated on 18-Sep-2024

Summary

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Official Symbol
ckb-4
Official Full Name
Choline/ethanolamine kinase
Primary source
WormBase:WBGene00000514
Locus tag
CELE_F22F7.5
See related
AllianceGenome:WB:WBGene00000514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables choline kinase activity. Involved in CDP-choline pathway. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKA (choline kinase alpha) and CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ckb-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (2106398..2109434, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Glycosyltransferase family 92 protein Neighboring gene Glycosyltransferase family 92 protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Glycosyltransferase family 92 protein Neighboring gene B3GNT1, Beta-1,3-N-acetylGucosamiNylTransferase 1, homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization. Gee P, et al. Biochim Biophys Acta, 2003 May 30. PMID 12758145
  2. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables choline kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ethanolamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CDP-choline pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in IRE1-mediated unfolded protein response HEP PubMed 
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Choline/ethanolamine kinase
NP_503573.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    2106398..2109434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071172.6 → NP_503573.1  Choline/ethanolamine kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_503573.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GZF3
    Conserved Domains (2) summary
    PLN02236
    Location:31 → 369
    PLN02236; choline kinase
    cd05156
    Location:43 → 370
    ChoK_euk; Euykaryotic Choline Kinase

RNA

  1. NR_132528.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

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