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cept-1 Choline/ethanolaminephosphotransferase 1-like [ Caenorhabditis elegans ]

Gene ID: 184847, updated on 18-Sep-2024

Summary

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Official Symbol
cept-1
Official Full Name
Choline/ethanolaminephosphotransferase 1-like
Primary source
WormBase:WBGene00009057
Locus tag
CELE_F22E10.5
See related
AllianceGenome:WB:WBGene00009057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable diacylglycerol cholinephosphotransferase activity and ethanolaminephosphotransferase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum membrane. Orthologous to several human genes including CEPT1 (choline/ethanolamine phosphotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See cept-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (12762078..12765898)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-27 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Interleukin cytokine-related protein 17.1 Neighboring gene Glutamate 5-kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease. Wang S, et al. Proc Natl Acad Sci U S A, 2014 Sep 23. PMID 25201965, Free PMC Article
  2. Gene inactivation confirms the identity of enzymes involved in nematode phosphorylcholine-N-glycan synthesis. Houston KM, et al. Mol Biochem Parasitol, 2008 Jan. PMID 17920136
  3. PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans. Svensk E, et al. PLoS Genet, 2013. PMID 24068966, Free PMC Article
  4. Epidermal Growth Factor Receptor Cell Survival Signaling Requires Phosphatidylcholine Biosynthesis. Crook M, et al. G3 (Bethesda), 2016 Nov 8. PMID 27605519, Free PMC Article
  5. A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Walker AK, et al. Cell, 2011 Nov 11. PMID 22035958, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables diacylglycerol cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ethanolaminephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Choline/ethanolaminephosphotransferase 1-like
NP_001257200.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    12762078..12765898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270271.4 → NP_001257200.1  Choline/ethanolaminephosphotransferase 1-like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257200.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EC09
    Conserved Domains (1) summary
    cl00453
    Location:28 → 392
    CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
Nucleotide Protein
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Gene LinkOut

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