U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

acd-1 DEgenerin Like [ Caenorhabditis elegans ]

Gene ID: 182852, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
acd-1
Official Full Name
DEgenerin Like
Primary source
WormBase:WBGene00016064
Locus tag
CELE_C24G7.2
See related
AllianceGenome:WB:WBGene00016064
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ligand-gated sodium channel activity. Involved in response to acidic pH and sodium ion transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in AMshL and AMshR. Orthologous to human ASIC4 (acid sensing ion channel subunit family member 4). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See acd-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
14
Sequence:
Chromosome: I; NC_003279.8 (4103698..4108167)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Muscle M-line assembly protein unc-89 Neighboring gene ncRNA Neighboring gene DEgenerin Like Neighboring gene DEgenerin Linked to Mechanosensation Neighboring gene Cyclin N-terminal domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans. Wang Y, et al. EMBO J, 2008 Sep 17. PMID 18701922, Free PMC Article
  2. Knockout of glial channel ACD-1 exacerbates sensory deficits in a C. elegans mutant by regulating calcium levels of sensory neurons. Wang Y, et al. J Neurophysiol, 2012 Jan. PMID 21994266, Free PMC Article
  3. The Na(+)-K(+)-ATPase is needed in glia of touch receptors for responses to touch in C. elegans. Johnson CK, et al. J Neurophysiol, 2020 May 1. PMID 32292107, Free PMC Article
  4. The glia of Caenorhabditis elegans. Oikonomou G, et al. Glia, 2011 Sep. PMID 21732423, Free PMC Article
  5. Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing degenerin/epithelial sodium channels. Kaulich E, et al. J Physiol, 2023 May. PMID 36200489, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the glial DEG/ENaC channel ACD-1 functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans
    Title: A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to acidic pH IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
DEgenerin Like
NP_491295.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4103698..4108167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058894.4 → NP_491295.2  DEgenerin Like [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491295.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    P91102
    Conserved Domains (2) summary
    TIGR00867
    Location:83 → 536
    deg-1; degenerin
    pfam00858
    Location:83 → 536
    ASC; Amiloride-sensitive sodium channel
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous