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cyp-35A1 CYtochrome P450 family [ Caenorhabditis elegans ]

Gene ID: 182176, updated on 2-Nov-2024

Summary

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Official Symbol
cyp-35A1
Official Full Name
CYtochrome P450 family
Primary source
WormBase:WBGene00015399
Locus tag
CELE_C03G6.14
See related
AllianceGenome:WB:WBGene00015399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); drug dependence (multiple); gastrointestinal system cancer (multiple); leukemia (multiple); and liver disease (multiple). Orthologous to several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2D6 (cytochrome P450 family 2 subfamily D member 6); and CYP2E1 (cytochrome P450 family 2 subfamily E member 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cyp-35A1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (7359929..7361773, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene 7TM GPCR serpentine receptor class x (Srx) domain-containing protein Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene CYtochrome P450 family Neighboring gene UPF0376 protein C03G6.5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis Elegans Mutants Predict Regulation of Fatty Acids and Endocannabinoids by the CYP-35A Gene Family. Aarnio V, et al. Front Pharmacol, 2011. PMID 21687507, Free PMC Article
  2. Expression profiling of five different xenobiotics using a Caenorhabditis elegans whole genome microarray. Reichert K, et al. Chemosphere, 2005 Oct. PMID 16168746
  3. CYP35: xenobiotically induced gene expression in the nematode Caenorhabditis elegans. Menzel R, et al. Arch Biochem Biophys, 2005 Jun 1. PMID 15910738
  4. Toxicity and metabolism of 3-bromopyruvate in Caenorhabditis elegans. Gu QL, et al. J Zhejiang Univ Sci B, 2020 Jan.. PMID 31898444, Free PMC Article
  5. A systematic gene expression screen of Caenorhabditis elegans cytochrome P450 genes reveals CYP35 as strongly xenobiotic inducible. Menzel R, et al. Arch Biochem Biophys, 2001 Nov 15. PMID 11697852

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
enables steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to xenobiotic stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
CYtochrome P450 family
NP_001343612.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    7359929..7361773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001356694.2 → NP_001343612.1  CYtochrome P450 family [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O02627
    Conserved Domains (1) summary
    cl12078
    Location:26 → 466
    p450; Cytochrome P450
Nucleotide Protein
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