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Ntsr2 neurotensin receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 18217, updated on 2-Nov-2024

Summary

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Official Symbol
Ntsr2provided by MGI
Official Full Name
neurotensin receptor 2provided by MGI
Primary source
MGI:MGI:108018
See related
Ensembl:ENSMUSG00000020591 AllianceGenome:MGI:108018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NT2R; NTR2; NTRL; NT-R-2
Summary
Enables G protein-coupled neurotensin receptor activity. Acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway and regulation of membrane potential. Located in membrane. Orthologous to human NTSR2 (neurotensin receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in genital fat pad adult (RPKM 70.4), cortex adult (RPKM 64.8) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Ntsr2 in Genome Data Viewer
Location:
12 A1.1; 12 7.98 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (16703477..16710223)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (16653443..16660236)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31636 Neighboring gene predicted gene, 53741 Neighboring gene STARR-seq mESC enhancer starr_31639 Neighboring gene lipin 1 Neighboring gene STARR-seq mESC enhancer starr_31643 Neighboring gene STARR-positive B cell enhancer ABC_E11503 Neighboring gene STARR-seq mESC enhancer starr_31645 Neighboring gene gene regulated by estrogen in breast cancer protein Neighboring gene E2F transcription factor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and expression of a variant isoform of the levocabastine-sensitive neurotensin receptor in the mouse central nervous system. Botto JM, et al. FEBS Lett, 1997 Jan 3. PMID 9001400
  2. Identification of the receptor subtype involved in the analgesic effect of neurotensin. Dubuc I, et al. J Neurosci, 1999 Jan 1. PMID 9870978, Free PMC Article
  3. Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice. Bredeloux P, et al. Behav Brain Res, 2006 Dec 15. PMID 17074405
  4. Neurotensin type 2 receptor is involved in fear memory in mice. Yamauchi R, et al. J Neurochem, 2007 Sep. PMID 17697051
  5. Involvement of NTS2 receptors in stress-induced analgesia. Lafrance M, et al. Neuroscience, 2010 Mar 17. PMID 20035838

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study shows that neurotensin receptor 2 expression remains constant throughout lifespan, and is predominantly expressed within glia.
    Title: Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan.
  2. Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala identify and validate Ntsr2-expressing neurons as a putative 'Fear-Off' population.
    Title: Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala.
  3. endogenous changes occur in NT and its receptors across multiple brain regions, and these likely support the emergence of some maternal behaviors.
    Title: Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice.
  4. findings suggest that NTS2 regulates ethanol-induced hypnosis and ethanol consumption
    Title: Increased ethanol consumption and preference in mice lacking neurotensin receptor type 2.
  5. These data support the regulation of baseline prepulse inhibition, acoustic startle response and locomotor activity by endogenous neurotensin acting at the NT2 receptor.
    Title: Effects of neurotensin-2 receptor deletion on sensorimotor gating and locomotor activity.
  6. Ntsr2 receptor subtype is necessary for normal dopaminergic function.
    Title: Hyperactivity of the dopaminergic system in NTS1 and NTS2 null mice.
  7. NTS2 receptors localized at the lumbar spinal cord participate to the disinhibition of descending pain control pathways.
    Title: Involvement of NTS2 receptors in stress-induced analgesia.
  8. These results suggest that Ntsr2 in astrocytes and neurons may have unique function like a modulation of fear memory in the mouse brain.
    Title: Neurotensin type 2 receptor is involved in fear memory in mice.
  9. Recycling ability depends on a single tyrosine residue
    Title: Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue.
  10. increase in jump latency induced by stimulation of NTS2 receptors is mediated by the release of an endogenous opioid receptor ligand
    Title: Interactions between NTS2 neurotensin and opioid receptors on two nociceptive responses assessed on the hot plate test in mice.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (5)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled neurotensin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled neurotensin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
neurotensin receptor type 2
Names
low affinity neurotensin receptor
low-affinity levocabastine-sensitive neurotensin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361702.2 → NP_001348631.1  neurotensin receptor type 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122228
    Conserved Domains (2) summary
    cd14964
    Location:35 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 233
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001361703.2 → NP_001348632.1  neurotensin receptor type 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122228
    Consensus CDS
    CCDS88315.1
    UniProtKB/TrEMBL
    A0A1Y7VN85
    Related
    ENSMUSP00000152290.2, ENSMUST00000220892.2
    Conserved Domains (2) summary
    cd14964
    Location:35 → 59
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:33 → 233
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_001412674.1 → NP_001399603.1  neurotensin receptor type 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122228

  4. NM_001412675.1 → NP_001399604.1  neurotensin receptor type 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122228

  5. NM_008747.3 → NP_032773.2  neurotensin receptor type 2 isoform 1

    See identical proteins and their annotated locations for NP_032773.2

    Status: VALIDATED

    Source sequence(s)
    AC122228
    Consensus CDS
    CCDS36407.1
    UniProtKB/Swiss-Prot
    P70310, Q8VIF5
    UniProtKB/TrEMBL
    Q920Q5
    Related
    ENSMUSP00000106693.2, ENSMUST00000111064.3
    Conserved Domains (1) summary
    pfam00001
    Location:85 → 358
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. NR_182023.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122228, AK081073
    Related
    ENSMUST00000222957.2

  2. NR_182024.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122228

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    16703477..16710223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70310.2 GenPept UniProtKB/Swiss-Prot:P70310

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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