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mig-2 [ Caenorhabditis elegans ]

Gene ID: 181344, updated on 11-Sep-2024

Summary

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Official Symbol
mig-2
Primary source
WormBase:WBGene00003239
Locus tag
CELE_C35C5.4
See related
AllianceGenome:WB:WBGene00003239
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables GTPase activity and protein kinase binding activity. Involved in several processes, including actin cytoskeleton organization; axon guidance; and engulfment of apoptotic cell. Located in cytoplasm; cytoplasmic side of plasma membrane; and neuron projection. Is expressed in several structures, including hermaphrodite distal tip cell; linker cell; neurons; somatic gonad precursor; and vulval cell. Used to study epilepsy. Orthologous to human RHOG (ras homolog family member G). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (11548608..11550692)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Thioredoxin reductase-like selenoprotein T homolog selt-1.1 Neighboring gene ncRNA Neighboring gene Transmembrane protein 164

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular signatures of cell migration in C. elegans Q neuroblasts. Ou G, et al. J Cell Biol, 2009 Apr 6. PMID 19349580, Free PMC Article
  2. A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans. Suzuki N, et al. EMBO Rep, 2001 Jun. PMID 11415987, Free PMC Article
  3. Role of a new Rho family member in cell migration and axon guidance in C. elegans. Zipkin ID, et al. Cell, 1997 Sep 5. PMID 9298900
  4. Hippo kinases maintain polarity during directional cell migration in Caenorhabditis elegans. Feng G, et al. EMBO J, 2017 Feb 1. PMID 28011581, Free PMC Article
  5. Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton. Tian D, et al. Curr Biol, 2015 May 4. PMID 25843030

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UNC-73, the C. elegans ortholog of Trio, is a guanine nucleotide exchange factor (GEF) upstream of both CED-10 and MIG-2 that is suppressed by CMRL1
    Title: Polarized Rac-dependent protrusions drive epithelial intercalation in the embryonic epidermis of C. elegans.
  2. active form of RhoG/MIG-2 directly binds to Anillin and recruits it to the leading edge of Q neuroblasts
    Title: Anillin Regulates Neuronal Migration and Neurite Growth by Linking RhoG to the Actin Cytoskeleton.
  3. Genetic interaction data with Rac GTPase activators and effectors suggest that CACN-1 acts specifically to inhibit the mig-2/Rac pathway, and in parallel to ced-10/Rac, to control distal tip cells.
    Title: CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans.
  4. results suggest that MAX-2 and MIG-2 play a crucial role in mediating the heavy metal stress response regulated by the KGB-1 pathway.
    Title: The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.
  5. MIG-2 plays an important role in defining the distinct migratory behavior of Q neuroblasts in C. elegans.
    Title: Molecular signatures of cell migration in C. elegans Q neuroblasts.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon extension involved in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chemorepulsion of axon IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dorsal/ventral axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in engulfment of apoptotic cell IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response HEP PubMed 
involved_in mesodermal cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motor neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of microtubule polymerization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode male tail tip morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in netrin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in organelle organization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to cell leading edge IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dorsal/ventral axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of dorsal/ventral axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to copper ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ras-related C3 botulinum toxin substrate 1;Signal recognition particle protein
NP_001300334.1
  • Confirmed by transcript evidence
NP_509931.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11548608..11550692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077530.5 → NP_509931.1  Ras-related C3 botulinum toxin substrate 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509931.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBV3
    Conserved Domains (2) summary
    smart00174
    Location:10 → 183
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd00157
    Location:8 → 178
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

  2. NM_001313405.4 → NP_001300334.1  Signal recognition particle protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0K3AYI6
    Conserved Domains (1) summary
    cl21455
    Location:1 → 66
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
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