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pkc-2 Protein kinase C;Protein kinase C-like 2 [ Caenorhabditis elegans ]

Gene ID: 181166, updated on 2-Nov-2024

Summary

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Official Symbol
pkc-2
Official Full Name
Protein kinase C;Protein kinase C-like 2
Primary source
WormBase:WBGene00004033
Locus tag
CELE_E01H11.1
See related
AllianceGenome:WB:WBGene00004033
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calcium,diacylglycerol-dependent serine/threonine kinase activity and protein serine kinase activity. Predicted to be involved in intracellular signal transduction. Located in several cellular components, including cytosol; neuron projection; and neuronal cell body. Is expressed in body wall musculature; intestine; neurons; somatic nervous system; and tail ganglion. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma (multiple); ovarian cancer; and spinocerebellar ataxia type 14. Orthologous to several human genes including PRKCA (protein kinase C alpha) and PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pkc-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Sequence:
Chromosome: X; NC_003284.9 (9364818..9386044)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene GH84 domain-containing protein Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene tRNA-Met Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LisH domain-containing protein Neighboring gene ncRNA Neighboring gene Zinc finger, CCHC-type

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and expression of the Caenorhabditis elegans protein kinase C2 gene. Origins and regulated expression of a family of Ca2+-activated protein kinase C isoforms. Islas-Trejo A, et al. J Biol Chem, 1997 Mar 7. PMID 9045693
  2. A Calcium- and Diacylglycerol-Stimulated Protein Kinase C (PKC), Caenorhabditis elegans PKC-2, Links Thermal Signals to Learned Behavior by Acting in Sensory Neurons and Intestinal Cells. Land M, et al. Mol Cell Biol, 2017 Oct 1. PMID 28716951, Free PMC Article
  3. A Necessary Role for PKC-2 and TPA-1 in Olfactory Memory and Synaptic AMPAR Trafficking in Caenorhabditis elegans. Stetak AL, et al. J Neurosci, 2024 Mar 6. PMID 38238075, Free PMC Article
  4. The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans. Sakai N, et al. PLoS One, 2017. PMID 28542414, Free PMC Article
  5. Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span. Feng H, et al. J Biol Chem, 2007 Oct 26. PMID 17728253

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Necessary Role for PKC-2 and TPA-1 in Olfactory Memory and Synaptic AMPAR Trafficking in Caenorhabditis elegans.
    Title: A Necessary Role for PKC-2 and TPA-1 in Olfactory Memory and Synaptic AMPAR Trafficking in Caenorhabditis elegans.
  2. Results show that PKC-2 is indispensable for thermotaxis behavior. PKC-2 acts in both AFD sensory neurons and intestinal cells to start and sustain cold-directed (cryophilic) migration, which constitutes an early phase of thermotaxis.
    Title: A Calcium- and Diacylglycerol-Stimulated Protein Kinase C (PKC), Caenorhabditis elegans PKC-2, Links Thermal Signals to Learned Behavior by Acting in Sensory Neurons and Intestinal Cells.
  3. data demonstrate that an individual DAG-dependent thermosensory behavior of an organism is effected specifically by the downstream PKC-2 phosphorylation of UNC-18 on Ser322 in AFD neurons.
    Title: PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Protein kinase C;Protein kinase C-like 2
NP_001024516.1
  • Confirmed by transcript evidence
NP_001024517.1
  • Confirmed by transcript evidence
NP_001123122.1
  • Confirmed by transcript evidence
NP_001359883.1
  • Partially confirmed by transcript evidence
NP_001360727.1
  • Confirmed by transcript evidence
NP_001360728.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9364818..9386044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129650.6 → NP_001123122.1  Protein kinase C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123122.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G8JY36
    Conserved Domains (4) summary
    cd04026
    Location:206 → 336
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:393 → 654
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05587
    Location:396 → 718
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:84 → 136
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  2. NM_001373417.3 → NP_001360728.1  Protein kinase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IKF6
    Conserved Domains (3) summary
    cd04026
    Location:206 → 336
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05587
    Location:396 → 718
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:84 → 134
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. NM_001029346.4 → NP_001024517.1  Protein kinase C-like 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024517.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90980, P90981, Q19024, Q8MQ87, Q8MQ88
    Conserved Domains (4) summary
    cd04026
    Location:161 → 291
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:348 → 609
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05587
    Location:351 → 673
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:39 → 91
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. NM_001029345.6 → NP_001024516.1  Protein kinase C-like 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024516.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90980
    Conserved Domains (4) summary
    cd04026
    Location:161 → 291
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:348 → 609
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05587
    Location:351 → 673
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:39 → 91
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  5. NM_001373418.2 → NP_001360727.1  Protein kinase C [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V6M3D7
    Conserved Domains (3) summary
    cd04026
    Location:232 → 362
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05587
    Location:422 → 744
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:110 → 160
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  6. NM_001373419.3 → NP_001359883.1  Protein kinase C-like 2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (3) summary
    cd04026
    Location:232 → 362
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    cd05587
    Location:422 → 744
    STKc_cPKC; Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C
    pfam00130
    Location:110 → 160
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P90980.2

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