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pcyt-1 Putative choline-phosphate cytidylyltransferase;choline-phosphate cytidylyltransferase [ Caenorhabditis elegans ]

Gene ID: 181021, updated on 2-Nov-2024

Summary

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Official Symbol
pcyt-1
Official Full Name
Putative choline-phosphate cytidylyltransferase;choline-phosphate cytidylyltransferase
Primary source
WormBase:WBGene00017241
Locus tag
CELE_F08C6.2
See related
AllianceGenome:WB:WBGene00017241
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables choline-phosphate cytidylyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Is expressed in head and nervous system. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline) and PCYT1B (phosphate cytidylyltransferase 1B, choline). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pcyt-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (7572357..7581055)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Band 7 domain-containing protein;Stomatin-1 Neighboring gene Vacuolar protein sorting-associated protein 52 homolog Neighboring gene Apyrase apy-1 Neighboring gene Zinc finger protein unc-98 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of hydrophobic amino acids required for lipid activation of C. elegans CTP:phosphocholine cytidylyltransferase. Braker JD, et al. Arch Biochem Biophys, 2009 Dec. PMID 19836342, Free PMC Article
  2. Gene inactivation confirms the identity of enzymes involved in nematode phosphorylcholine-N-glycan synthesis. Houston KM, et al. Mol Biochem Parasitol, 2008 Jan. PMID 17920136
  3. Overactive EGF signaling promotes uv1 cell survival via increased phosphatidylcholine levels and suppression of SBP-1. Crook M, et al. MicroPubl Biol, 2020 Jun 29. PMID 32666045, Free PMC Article
  4. Caenorhabditis elegans numb inhibits endocytic recycling by binding TAT-1 aminophospholipid translocase. Nilsson L, et al. Traffic, 2011 Dec. PMID 21917090
  5. Epidermal Growth Factor Receptor Cell Survival Signaling Requires Phosphatidylcholine Biosynthesis. Crook M, et al. G3 (Bethesda), 2016 Nov 8. PMID 27605519, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables choline-phosphate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline-phosphate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables choline-phosphate cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Putative choline-phosphate cytidylyltransferase;choline-phosphate cytidylyltransferase
NP_001033539.1
  • Confirmed by transcript evidence
NP_001033540.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7572357..7581055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001038450.5 → NP_001033539.1  Putative choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001033539.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49583
    Conserved Domains (1) summary
    cd02174
    Location:79 → 228
    CCT; CTP:phosphocholine cytidylyltransferase

  2. NM_001038451.3 → NP_001033540.1  choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001033540.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3HKC4
    Conserved Domains (1) summary
    cd02174
    Location:71 → 220
    CCT; CTP:phosphocholine cytidylyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49583.2

Gene LinkOut

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