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abts-4 Anion exchange protein [ Caenorhabditis elegans ]

Gene ID: 180943, updated on 18-Sep-2024

Summary

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Official Symbol
abts-4
Official Full Name
Anion exchange protein
Primary source
WormBase:WBGene00019844
Locus tag
CELE_R03E9.3
See related
AllianceGenome:WB:WBGene00019844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable anion:anion antiporter activity. Predicted to be involved in bicarbonate transport; regulation of intracellular pH; and transmembrane transport. Located in basolateral plasma membrane. Is expressed in intestine and nervous system. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)); SLC4A2 (solute carrier family 4 member 2); and SLC4A3 (solute carrier family 4 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See abts-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
20
Sequence:
Chromosome: X; NC_003284.9 (6747296..6761738, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Mad-like protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Inward rectifier potassium channel irk-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The abts and sulp families of anion transporters from Caenorhabditis elegans. Sherman T, et al. Am J Physiol Cell Physiol, 2005 Aug. PMID 15814591
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables monoatomic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inorganic anion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Anion exchange protein
NP_001024826.2
  • Confirmed by transcript evidence
NP_001123169.1
  • Partially confirmed by transcript evidence
NP_001123170.1
  • Partially confirmed by transcript evidence
NP_001380003.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6747296..6761738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029655.6 → NP_001024826.2  Anion exchange protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024826.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q58QG8
    Conserved Domains (3) summary
    TIGR00834
    Location:81 → 955
    ae; anion exchange protein
    pfam07565
    Location:100 → 365
    Band_3_cyto; Band 3 cytoplasmic domain
    cl23746
    Location:415 → 879
    HCO3_cotransp; HCO3- transporter family

  2. NM_001129697.5 → NP_001123169.1  Anion exchange protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123169.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q58G79
    Conserved Domains (3) summary
    TIGR00834
    Location:81 → 935
    ae; anion exchange protein
    pfam07565
    Location:186 → 365
    Band_3_cyto; Band 3 cytoplasmic domain
    cl23746
    Location:415 → 873
    HCO3_cotransp; HCO3- transporter family

  3. NM_001392793.1 → NP_001380003.1  Anion exchange protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q45EK3
    Conserved Domains (1) summary
    cl23746
    Location:414 → 865
    Xan_ur_permease; Permease family

  4. NM_001129698.4 → NP_001123170.1  Anion exchange protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123170.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L0C4
    Conserved Domains (3) summary
    TIGR00834
    Location:81 → 873
    ae; anion exchange protein
    pfam07565
    Location:186 → 365
    Band_3_cyto; Band 3 cytoplasmic domain
    cl23746
    Location:415 → 873
    HCO3_cotransp; HCO3- transporter family
Nucleotide Protein
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