U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

sft-4 Surfeit locus protein 4 homolog [ Caenorhabditis elegans ]

Gene ID: 180843, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
sft-4
Official Full Name
Surfeit locus protein 4 homolog
Primary source
WormBase:WBGene00004788
Locus tag
CELE_C54H2.5
See related
AllianceGenome:WB:WBGene00004788
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cargo receptor activity. Involved in several processes, including negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of vulval development; and protein exit from endoplasmic reticulum. Located in endoplasmic reticulum exit site and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary muscle; excretory cell; hypodermis; reproductive system; and vulval precursor cell. Orthologous to human SURF4 (surfeit 4). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See sft-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (5778875..5780722, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene C2 NT-type domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene ZP domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Large-scale identification of Caenorhabditis elegans proteins by multidimensional liquid chromatography-tandem mass spectrometry. Mawuenyega KG, et al. J Proteome Res, 2003 Jan-Feb. PMID 12643540
  2. SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization. Saegusa K, et al. J Cell Biol, 2018 Jun 4. PMID 29643117, Free PMC Article
  3. Surfeit locus gene homologs are widely distributed in invertebrate genomes. Armes N, et al. Mol Cell Biol, 1996 Oct. PMID 8816471, Free PMC Article
  4. Functional characterization in Caenorhabditis elegans of transmembrane worm-human orthologs. Henricson A, et al. BMC Genomics, 2004 Nov 8. PMID 15533247, Free PMC Article
  5. An in vivo EGF receptor localization screen in C. elegans Identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling. Haag A, et al. PLoS Genet, 2014 May. PMID 24785082, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cargo receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of vulval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein exit from endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Surfeit locus protein 4 homolog
NP_508970.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5778875..5780722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076569.12 → NP_508970.1  Surfeit locus protein 4 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508970.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18006, Q18864
    Conserved Domains (1) summary
    pfam02077
    Location:11 → 277
    SURF4; SURF4 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18864.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous