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argn-1 Arginase [ Caenorhabditis elegans ]

Gene ID: 180830, updated on 2-Nov-2024

Summary

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Official Symbol
argn-1
Official Full Name
Arginase
Primary source
WormBase:WBGene00020658
Locus tag
CELE_T21F4.1
See related
AllianceGenome:WB:WBGene00020658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable arginase activity and manganese ion binding activity. Involved in innate immune response. Predicted to be active in cytosol. Is expressed in hypodermal cell. Used to study hyperargininemia. Human ortholog(s) of this gene implicated in asthma; hepatocellular carcinoma; and hyperargininemia. Orthologous to human ARG1 (arginase 1) and ARG2 (arginase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See argn-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (5630023..5631825)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene PH domain-containing protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RING-type domain-containing protein Neighboring gene SGF29 C-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans. Tang R, et al. J Genet Genomics, 2020 Mar 20. PMID 32305173
  2. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
  3. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans.
    Title: Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables arginase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arginine catabolic process to ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response HEP PubMed 
involved_in urea cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Arginase
NP_001370979.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5630023..5631825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383585.1 → NP_001370979.1  Arginase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1X7RC97
    Conserved Domains (1) summary
    cd09989
    Location:12 → 296
    Arginase; Arginase family
Nucleotide Protein
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