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hyl-2 Ceramide synthase hyl-2 [ Caenorhabditis elegans ]

Gene ID: 180743, updated on 2-Nov-2024

Summary

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Official Symbol
hyl-2
Official Full Name
Ceramide synthase hyl-2
Primary source
WormBase:WBGene00002044
Locus tag
CELE_K02G10.6
See related
AllianceGenome:WB:WBGene00002044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to be located in membrane. Is expressed in head; hypodermis; intestine; tail; and terminal bulb. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9. Orthologous to several human genes including CERS6 (ceramide synthase 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hyl-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (4696754..4699461, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Solute carrier organic anion transporter family member Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging. Jazwinski SM. Ageing Res Rev, 2015 Sep. PMID 25555678, Free PMC Article
  2. Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition. Zhu H, et al. J Biol Chem, 2024 Jun. PMID 38677510, Free PMC Article
  3. The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging. Staab TA, et al. Aging (Albany NY), 2023 Feb 13. PMID 36787434, Free PMC Article
  4. Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Menuz V, et al. Science, 2009 Apr 17. PMID 19372430
  5. High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans. Alcántar-Fernández J, et al. PLoS One, 2019. PMID 31846489, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition.
    Title: Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition.
  2. data indicate that specific ceramides produced by HYL-2 confer resistance to anoxia
    Title: Protection of C. elegans from anoxia by HYL-2 ceramide synthase.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
NOT enables sphingosine N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingosine N-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ceramide synthase hyl-2
NP_508803.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4696754..4699461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076402.9 → NP_508803.3  Ceramide synthase hyl-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508803.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7Z139
    Conserved Domains (1) summary
    smart00724
    Location:86 → 298
    TLC; TRAM, LAG1 and CLN8 homology domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z139.1

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