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hosl-1 Hormone-sensitive lipase [ Caenorhabditis elegans ]

Gene ID: 180737, updated on 2-Nov-2024

Summary

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Official Symbol
hosl-1
Official Full Name
Hormone-sensitive lipase
Primary source
WormBase:WBGene00016704
Locus tag
CELE_C46C11.1
See related
AllianceGenome:WB:WBGene00016704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable sterol ester esterase activity and triacylglycerol lipase activity. Predicted to be involved in triglyceride catabolic process. Predicted to be active in cytosol. Is expressed in several structures, including arcade cell; hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hosl-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
14
Sequence:
Chromosome: X; NC_003284.9 (4637121..4643695)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SoLute Carrier family Related Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene Equilibrative nucleoside transporter 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans Perilipin Is Implicated in Cold-Induced Lipolysis and Inhibits Autophagy in Early Embryos. Kassak F, et al. Folia Biol (Praha), 2020. PMID 34087974
  2. Piceatannol Reduces Fat Accumulation in Caenorhabditis elegans. Shen P, et al. J Med Food, 2017 Sep. PMID 28514198, Free PMC Article
  3. The cAMP-PKA pathway-mediated fat mobilization is required for cold tolerance in C. elegans. Liu F, et al. Sci Rep, 2017 Apr 4. PMID 28377576, Free PMC Article
  4. Cranberry Product Decreases Fat Accumulation in Caenorhabditis elegans. Sun Q, et al. J Med Food, 2016 Apr. PMID 26991055, Free PMC Article
  5. Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival. Narbonne P, et al. Nature, 2009 Jan 8. PMID 19052547

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables sterol ester esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables triacylglycerol lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Hormone-sensitive lipase
NP_001041228.1
  • Confirmed by transcript evidence
NP_001367667.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4637121..4643695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047763.5 → NP_001041228.1  Hormone-sensitive lipase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041228.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q966P1
    Conserved Domains (3) summary
    COG0657
    Location:380 → 487
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:60 → 365
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:380 → 527
    Abhydrolase; alpha/beta hydrolases

  2. NM_001380950.1 → NP_001367667.1  Hormone-sensitive lipase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E7FM69
    Conserved Domains (2) summary
    pfam06350
    Location:25 → 330
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:345 → 452
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
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