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acly-1 putative ATP-citrate synthase [ Caenorhabditis elegans ]

Gene ID: 180485, updated on 2-Nov-2024

Summary

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Official Symbol
acly-1
Official Full Name
putative ATP-citrate synthase
Primary source
WormBase:WBGene00016995
Locus tag
CELE_D1005.1
See related
AllianceGenome:WB:WBGene00016995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP citrate synthase activity. Predicted to be involved in acetyl-CoA biosynthetic process and fatty acid biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human ACLY (ATP citrate lyase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acly-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (1479542..1484087)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Signal peptide-containing protein Neighboring gene tRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene C-type lectin domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level. Zhu D, et al. Sci Adv, 2020 Jul. PMID 32789178, Free PMC Article
  2. KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain. An SWA, et al. Aging Cell, 2019 Jun. PMID 30773781, Free PMC Article
  3. Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids. Möller S, et al. Aging (Albany NY), 2020 Jul 7. PMID 32634117, Free PMC Article
  4. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
  5. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP citrate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP citrate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in citrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative ATP-citrate synthase
NP_508280.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    1479542..1484087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075879.6 → NP_508280.1  putative ATP-citrate synthase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508280.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53585
    Conserved Domains (7) summary
    cd06100
    Location:856 → 1096
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1 → 431
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:492 → 1097
    PLN02522; ATP citrate (pro-S)-lyase
    pfam00549
    Location:660 → 785
    Ligase_CoA; CoA-ligase
    pfam02629
    Location:496 → 600
    CoA_binding; CoA binding domain
    pfam16114
    Location:258 → 432
    Citrate_bind; ATP citrate lyase citrate-binding
    cl17255
    Location:8 → 208
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53585.1

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