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ifd-2 Intermediate filament protein ifd-2 [ Caenorhabditis elegans ]

Gene ID: 180430, updated on 2-Nov-2024

Summary

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Official Symbol
ifd-2
Official Full Name
Intermediate filament protein ifd-2
Primary source
WormBase:WBGene00002058
Locus tag
CELE_F25E2.4
See related
AllianceGenome:WB:WBGene00002058
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including heterochromatin formation; nucleus organization; and protein localization to nuclear envelope. Predicted to be located in cytoplasm and intermediate filament. Predicted to be active in nuclear envelope and nuclear lamina. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); ectodermal dysplasia (multiple); hair disease (multiple); intrinsic cardiomyopathy (multiple); and myopathy (multiple). Orthologous to several human genes including DES (desmin); GFAP (glial fibrillary acidic protein); and INA (internexin neuronal intermediate filament protein alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ifd-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (813854..815929, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Acyl-CoA thioesterase II Neighboring gene ncRNA Neighboring gene Smad protein daf-3 Neighboring gene ANAPC4_WD40 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers. Arnold ML, et al. Nat Commun, 2023 Jul 24. PMID 37488107, Free PMC Article
  2. Promiscuous Dimerization Between the Caenorhabditis elegans IF Proteins and a Hypothesis to Explain How Multiple IFs Persist Over Evolutionary Time. Karabinos A, et al. J Mol Evol, 2019 Sep. PMID 31407015
  3. Intermediate filament (IF) proteins IFA-1 and IFB-1 represent a basic heteropolymeric IF cytoskeleton of nematodes: A molecular phylogeny of nematode IFs. Karabinos A. Gene, 2019 Apr 15. PMID 30641223
  4. Intermediate filament network perturbation in the C. elegans intestine causes systemic dysfunctions. Geisler F, et al. Elife, 2023 Jun 7. PMID 37283438, Free PMC Article
  5. Analysis of the novel excretory cell expressed ECP-1 protein and its proposed ECP-1/IFC-2 fusion protein EXC-2 in the nematode Caenorhabditis elegans. Karabinos A, et al. Gene Expr Patterns, 2019 Dec. PMID 31207388

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear pore localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear lamina IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Intermediate filament protein ifd-2
NP_508160.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    813854..815929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075759.7 → NP_508160.1  Intermediate filament protein ifd-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508160.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19782
    Conserved Domains (1) summary
    pfam00038
    Location:55 → 402
    Filament; Intermediate filament protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19782.1

Gene LinkOut

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