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ipla-3 Phospholipase A(2);phospholipase A2 [ Caenorhabditis elegans ]

Gene ID: 180354, updated on 2-Nov-2024

Summary

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Official Symbol
ipla-3
Official Full Name
Phospholipase A(2);phospholipase A2
Primary source
WormBase:WBGene00012319
Locus tag
CELE_W07A8.2
See related
AllianceGenome:WB:WBGene00012319
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin filament bundle assembly. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ipla-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
19
Sequence:
Chromosome: V; NC_003283.11 (20717869..20729272, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene F-box C protein Neighboring gene F-box associated domain-containing protein Neighboring gene J domain-containing protein Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling. Schmeisser S, et al. Cell Rep, 2019 Dec 24. PMID 31875559
  2. Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform. Morrison K, et al. J Biol Chem, 2012 Nov 9. PMID 23007400, Free PMC Article
  3. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478
  4. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
  5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Phospholipase A(2);phospholipase A2
NP_001256946.1
  • Confirmed by transcript evidence
NP_001366900.1
  • Confirmed by transcript evidence
NP_001367027.1
  • Confirmed by transcript evidence
NP_001367163.1
  • Confirmed by transcript evidence
NP_001368732.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20717869..20729272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380888.1 → NP_001366900.1  phospholipase A2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBV1
    Conserved Domains (5) summary
    cd07212
    Location:693 → 998
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    COG0666
    Location:442 → 590
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:493 → 522
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:494 → 545
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:323 → 418
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001380887.2 → NP_001367027.1  phospholipase A2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EC56
    Conserved Domains (5) summary
    cd07212
    Location:691 → 996
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    COG0666
    Location:440 → 588
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:491 → 520
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:492 → 543
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:321 → 416
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_001380885.1 → NP_001368732.1  phospholipase A2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A486WUW0
    Conserved Domains (5) summary
    cd07212
    Location:715 → 1020
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    COG0666
    Location:464 → 612
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:515 → 544
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:516 → 567
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:345 → 440
    Ank_2; Ankyrin repeats (3 copies)

  4. NM_001380886.1 → NP_001367163.1  phospholipase A2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGD6
    Conserved Domains (5) summary
    cd07212
    Location:717 → 1022
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    COG0666
    Location:466 → 614
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:517 → 546
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:518 → 569
    Ank_4; Ankyrin repeats (many copies)
    pfam12796
    Location:347 → 442
    Ank_2; Ankyrin repeats (3 copies)

  5. NM_001270017.3 → NP_001256946.1  Phospholipase A(2) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256946.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3Y5P2
    Conserved Domains (1) summary
    cl11396
    Location:1 → 135
    Patatin_and_cPLA2; Patatins and Phospholipases
Nucleotide Protein
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