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ttx-1 Homeobox protein ttx-1 [ Caenorhabditis elegans ]

Gene ID: 180313, updated on 2-Nov-2024

Summary

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Official Symbol
ttx-1
Official Full Name
Homeobox protein ttx-1
Primary source
WormBase:WBGene00006652
Locus tag
CELE_Y113G7A.6
See related
AllianceGenome:WB:WBGene00006652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of plasma membrane bounded cell projection assembly; and thermosensory behavior. Located in nucleus. Is expressed in head neurons and pharyngeal cell. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Orthologous to several human genes including OTX1 (orthodenticle homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ttx-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (20053719..20064176, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene CX domain-containing protein Neighboring gene Serpentine Receptor, class H Neighboring gene NADPH-dependent diflavin oxidoreductase 1 Neighboring gene ncRNA Neighboring gene 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase;m7GpppX diphosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modulation of Caenorhabditis elegans chemotaxis by cultivation and assay temperatures. Adachi R, et al. Neurosci Res, 2008 Mar. PMID 18192049
  2. Exposure to metals induces morphological and functional alteration of AFD neurons in nematode Caenorhabditis elegans. Xing X, et al. Environ Toxicol Pharmacol, 2009 Jul. PMID 21783989
  3. Thermotaxis in Caenorhabditis elegans analyzed by measuring responses to defined Thermal stimuli. Ryu WS, et al. J Neurosci, 2002 Jul 1. PMID 12097525, Free PMC Article
  4. Graphene oxide-induced neurotoxicity on neurotransmitters, AFD neurons and locomotive behavior in Caenorhabditis elegans. Kim M, et al. Neurotoxicology, 2020 Mar. PMID 31862286
  5. Step response analysis of thermotaxis in Caenorhabditis elegans. Zariwala HA, et al. J Neurosci, 2003 May 15. PMID 12764126, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of microvillus assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thermosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Homeobox protein ttx-1
NP_001024212.1
  • Confirmed by transcript evidence
NP_001024213.1
  • Partially confirmed by transcript evidence
NP_001129914.1
  • Confirmed by transcript evidence
NP_001317838.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20053719..20064176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029042.5 → NP_001024213.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024213.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2Y9
    Conserved Domains (1) summary
    pfam00046
    Location:150 → 203
    Homeobox; Homeobox domain

  2. NM_001330887.2 → NP_001317838.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A168HA93
    Conserved Domains (1) summary
    pfam00046
    Location:191 → 244
    Homeobox; Homeobox domain

  3. NM_001029041.3 → NP_001024212.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024212.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A168HA93, B5QSI6, Q95W16, Q95W17, Q95W18, Q9U2Y9, Q9U2Z0
    Conserved Domains (1) summary
    pfam00046
    Location:203 → 256
    Homeobox; Homeobox domain

  4. NM_001136442.4 → NP_001129914.1  Homeobox protein ttx-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129914.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5QSI6
    Conserved Domains (1) summary
    pfam00046
    Location:166 → 219
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9U2Z0.2

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