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csn-1 COP9 signalosome complex subunit 1 [ Caenorhabditis elegans ]

Gene ID: 180168, updated on 2-Nov-2024

Summary

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Official Symbol
csn-1
Official Full Name
COP9 signalosome complex subunit 1
Primary source
WormBase:WBGene00000813
Locus tag
CELE_Y59A8A.1
See related
AllianceGenome:WB:WBGene00000813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in oogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of COP9 signalosome. Orthologous to human GPS1 (G protein pathway suppressor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See csn-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (17861368..17870651, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Ribosome-binding protein 1 Neighboring gene SAM-dependent methyltransferase Neighboring gene PHD-type domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans. Pintard L, et al. Curr Biol, 2003 May 27. PMID 12781129
  2. Genome-wide prediction of C. elegans genetic interactions. Zhong W, et al. Science, 2006 Mar 10. PMID 16527984
  3. Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Mehta R, et al. Science, 2009 May 29. PMID 19372390, Free PMC Article
  4. CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Luke-Glaser S, et al. Mol Cell Biol, 2007 Jun. PMID 17403899, Free PMC Article
  5. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 1
NP_001370106.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    17861368..17870651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383483.2 → NP_001370106.1  COP9 signalosome complex subunit 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9GS00
    Conserved Domains (2) summary
    pfam01399
    Location:393 → 495
    PCI; PCI domain
    pfam10602
    Location:163 → 378
    RPN7; 26S proteasome subunit RPN7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GS00.1

Gene LinkOut

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