crm-1 Cysteine-rich motor neuron 1 protein;Cysteine-rich motor neuron 1 protein-like [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: crm-1
Official Full Name: Cysteine-rich motor neuron 1 protein;Cysteine-rich motor neuron 1 protein-like
Primary source: WormBase:WBGene00007103
Locus tag: CELE_B0024.14
See related: AllianceGenome:WB:WBGene00007103
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region and membrane. Predicted to be active in plasma membrane. Is expressed in intestine; nervous system; pharynx; and reproductive system. Orthologous to human CRIM1 (cysteine rich transmembrane BMP regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See crm-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 17

Sequence:: Chromosome: V; NC_003283.11 (10322283..10332112, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that SOD1 mutants are removed from the nucleus by CRM1 as a defense mechanism against proteotoxicity of misfolded SOD1 in the nucleus.
Title: Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus.
ectopic expression experiments reveal that crm-1 gene products act outside the DBL-1 producing cells and function non-autonomously to facilitate dbl/sma pathway signaling to control body size.
Title: crm-1 facilitates BMP signaling to control body size in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

B0024.14 (e-PCR)
- UniSTS:307171

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Cysteine-rich motor neuron 1 protein;Cysteine-rich motor neuron 1 protein-like

NP_001256210.1

Confirmed by transcript evidence

NP_741616.2

Confirmed by transcript evidence

NP_741617.2

Confirmed by transcript evidence

NP_741618.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10322283..10332112 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171530.7 → NP_741617.2 Cysteine-rich motor neuron 1 protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741617.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EEX3

Conserved Domains (1) summary

cl17735
Location:541 → 592

VWC; von Willebrand factor type C domain
NM_171529.7 → NP_741616.2 Cysteine-rich motor neuron 1 protein-like [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741616.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EF34

Conserved Domains (2) summary

pfam00219
Location:28 → 76

IGFBP; Insulin-like growth factor binding protein

cl17735
Location:607 → 658

VWC; von Willebrand factor type C domain
NM_171935.7 → NP_741618.2 Cysteine-rich motor neuron 1 protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741618.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EBZ2

Conserved Domains (1) summary

cl17735
Location:541 → 592

VWC; von Willebrand factor type C domain
NM_001269281.4 → NP_001256210.1 Cysteine-rich motor neuron 1 protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256210.1

Status: REVIEWED

UniProtKB/TrEMBL

E1B6S3

Conserved Domains (1) summary

cl17735
Location:516 → 567

VWC; von Willebrand factor type C domain