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acl-2 1-acylglycerol-3-phosphate O-acyltransferase;Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [ Caenorhabditis elegans ]

Gene ID: 179398, updated on 2-Nov-2024

Summary

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Official Symbol
acl-2
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase;Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2
Primary source
WormBase:WBGene00011543
Locus tag
CELE_T06E8.1
See related
AllianceGenome:WB:WBGene00011543
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidic acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1 and lipodystrophy. Orthologous to human AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1) and AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acl-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (10028150..10031092, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Plant Late Embryo Abundant (LEA) related Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondria-type GPAT is required for mitochondrial fusion. Ohba Y, et al. EMBO J, 2013 May 2. PMID 23572076, Free PMC Article
  2. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidic acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1-acylglycerol-3-phosphate O-acyltransferase;Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2
NP_001256175.1
  • Confirmed by transcript evidence
NP_001256176.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    10028150..10031092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269246.5 → NP_001256175.1  Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256175.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22267
    Conserved Domains (2) summary
    cd07989
    Location:70 → 250
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
    COG0204
    Location:62 → 282
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]

  2. NM_001269247.3 → NP_001256176.1  1-acylglycerol-3-phosphate O-acyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256176.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I2HA82
    Conserved Domains (1) summary
    cd07989
    Location:1 → 101
    LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22267.1

Gene LinkOut

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