acl-6 Phospholipid/glycerol acyltransferase domain-containing protein;putative glycerol-3-phosphate acyltransferase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: acl-6
Official Full Name: Phospholipid/glycerol acyltransferase domain-containing protein;putative glycerol-3-phosphate acyltransferase, mitochondrial
Primary source: WormBase:WBGene00017261
Locus tag: CELE_F08F3.2
See related: AllianceGenome:WB:WBGene00017261
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in several processes, including glycerol-3-phosphate metabolic process; phospholipid biosynthetic process; and triglyceride biosynthetic process. Located in mitochondrion. Is expressed in muscle cell. Orthologous to several human genes including GPAM (glycerol-3-phosphate acyltransferase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See acl-6 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 12

Sequence:: Chromosome: V; NC_003283.11 (5433386..5437095)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysophosphatidic acid produced by Mitochondrial GPAT functions not only as a precursor for glycerolipid synthesis but also as an essential factor of mitochondrial fusion.
Title: Mitochondria-type GPAT is required for mitochondrial fusion.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F08F3.2 (e-PCR)
- UniSTS:309598

F08F3.8 (e-PCR)
- UniSTS:309601

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-3-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cellular lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerophospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Phospholipid/glycerol acyltransferase domain-containing protein;putative glycerol-3-phosphate acyltransferase, mitochondrial

NP_001023769.1

Confirmed by transcript evidence

NP_001023770.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

5433386..5437095

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028599.5 → NP_001023770.1 Phospholipid/glycerol acyltransferase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023770.1

Status: REVIEWED

UniProtKB/TrEMBL

G8JY39

Conserved Domains (2) summary

cd07993
Location:1 → 190

LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

COG2937
Location:2 → 528

PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
NM_001028598.5 → NP_001023769.1 putative glycerol-3-phosphate acyltransferase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023769.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22949

Conserved Domains (2) summary

cd07993
Location:138 → 350

LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

COG2937
Location:58 → 688

PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]