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exc-14 RING-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 178892, updated on 2-Nov-2024

Summary

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Official Symbol
exc-14
Official Full Name
RING-type domain-containing protein
Primary source
WormBase:WBGene00019649
Locus tag
CELE_K11D12.9
See related
AllianceGenome:WB:WBGene00019649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Orthologous to human MUL1 (mitochondrial E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See exc-14 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (5042376..5046203, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene C2H2-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquitin-mediated pathways in C. elegans. Kipreos ET. WormBook, 2005 Dec 1. PMID 18050424, Free PMC Article
  2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RING-type domain-containing protein
NP_504354.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5042376..5046203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071953.5 → NP_504354.1  RING-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504354.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44624
    Conserved Domains (3) summary
    COG1196
    Location:112 → 272
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00162
    Location:352 → 388
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam13920
    Location:351 → 393
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
Nucleotide Protein
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