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acc-1 Acetylcholine-gated chloride channel subunit acc-1;Ligand-gated ion channel 50 [ Caenorhabditis elegans ]

Gene ID: 177799, updated on 2-Nov-2024

Summary

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Official Symbol
acc-1
Official Full Name
Acetylcholine-gated chloride channel subunit acc-1;Ligand-gated ion channel 50
Primary source
WormBase:WBGene00010275
Locus tag
CELE_F58G6.4
See related
AllianceGenome:WB:WBGene00010275
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and neurotransmitter receptor activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane and postsynapse. Predicted to be part of transmembrane transporter complex. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in ganglia and neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See acc-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
15
Sequence:
Chromosome: IV; NC_003282.8 (9658053..9663983)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Copper transport protein Neighboring gene Copper transport protein Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-34 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Investigating the function and possible biological role of an acetylcholine-gated chloride channel subunit (ACC-1) from the parasitic nematode Haemonchus contortus. Callanan MK, et al. Int J Parasitol Drugs Drug Resist, 2018 Dec. PMID 30401619, Free PMC Article
  2. Characterization of cys-loop receptor genes involved in inhibitory amine neurotransmission in parasitic and free living nematodes. Beech RN, et al. Parasitol Int, 2013 Dec. PMID 23602737
  3. Locomotion modulates olfactory learning through proprioception in C. elegans. Zhan X, et al. Nat Commun, 2023 Jul 27. PMID 37500635, Free PMC Article
  4. An hourglass circuit motif transforms a motor program via subcellularly localized muscle calcium signaling and contraction. Sando SR, et al. Elife, 2021 Jul 2. PMID 34212858, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transmembrane transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Acetylcholine-gated chloride channel subunit acc-1;Ligand-gated ion channel 50
NP_001293865.1
  • Confirmed by transcript evidence
NP_501715.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9658053..9663983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069314.8 → NP_501715.1  Acetylcholine-gated chloride channel subunit acc-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501715.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21005
    Conserved Domains (1) summary
    cl27321
    Location:35 → 449
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

  2. NM_001306936.3 → NP_001293865.1  Ligand-gated ion channel 50 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293865.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ACH3
    Conserved Domains (3) summary
    TIGR00860
    Location:39 → 453
    LIC; Cation transporter family protein
    pfam02931
    Location:38 → 243
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:251 → 450
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21005.2

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