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nap-1 Nucleosome assembly protein 1-like 1 [ Caenorhabditis elegans ]

Gene ID: 177636, updated on 18-Sep-2024

Summary

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Official Symbol
nap-1
Official Full Name
Nucleosome assembly protein 1-like 1
Primary source
WormBase:WBGene00017075
Locus tag
CELE_D2096.8
See related
AllianceGenome:WB:WBGene00017075
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cholesterol binding activity. Predicted to be involved in nucleosome assembly. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to several human genes including NAP1L1 (nucleosome assembly protein 1 like 1) and NAP1L4 (nucleosome assembly protein 1 like 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See nap-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (8377705..8379319, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene P-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene DDE-1 domain-containing protein;ELYS domain-containing protein;FA_FANCE domain-containing protein;Uncharacterized protein Neighboring gene ncRNA Neighboring gene PRA1 family protein Neighboring gene Neuropeptide-Like Protein Neighboring gene C6 domain-containing protein Neighboring gene GAR domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Caenorhabditis elegans Nucleosome Assembly Protein 1 Uncovers the Role of Acidic Tails in Histone Binding. Sarkar P, et al. Biochemistry, 2019 Jan 15. PMID 30521320
  2. NSBP-1 mediates the effects of cholesterol on insulin/IGF-1 signaling in Caenorhabditis elegans. Cheong MC, et al. Cell Mol Life Sci, 2013 May. PMID 23255046, Free PMC Article
  3. spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily. Wen C, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11114162, Free PMC Article
  4. Forward chemical genetic approach identifies new role for GAPDH in insulin signaling. Min J, et al. Nat Chem Biol, 2007 Jan. PMID 17115034
  5. Quantitative mass spectrometry identifies insulin signaling targets in C. elegans. Dong MQ, et al. Science, 2007 Aug 3. PMID 17673661

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular characterization of NAP1 chaperoning activity toward histones H2A/H2B has been reported.
    Title: Structural Insights into ceNAP1 Chaperoning Activity toward ceH2A-H2B.
  2. The role of NAP1 acidic domains in the histone binding.
    Title: Characterization of Caenorhabditis elegans Nucleosome Assembly Protein 1 Uncovers the Role of Acidic Tails in Histone Binding.
  3. Nematode sterol-binding protein 1 (NSBP-1), a homolog of nucleosome assembly protein 1 (NAP1) in mammals influences many biological processes mediated by insulin signaling, such as longevity, dauer formation, fat storage, and resistance to oxidative stress.
    Title: NSBP-1 mediates the effects of cholesterol on insulin/IGF-1 signaling in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cholesterol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nucleosome assembly protein 1-like 1
NP_501422.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8377705..8379319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069021.9 → NP_501422.1  Nucleosome assembly protein 1-like 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501422.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19007
    Conserved Domains (1) summary
    pfam00956
    Location:28 → 291
    NAP; Nucleosome assembly protein (NAP)
Nucleotide Protein
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