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rabs-5 FYVE-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177603, updated on 2-Nov-2024

Summary

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Official Symbol
rabs-5
Official Full Name
FYVE-type domain-containing protein
Primary source
WormBase:WBGene00021538
Locus tag
CELE_Y42H9AR.3
See related
AllianceGenome:WB:WBGene00021538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Involved in pinocytosis and receptor-mediated endocytosis. Is expressed in PQR; amphid neurons; head; phasmid neurons; and ray neurons. Orthologous to human RBSN (rabenosyn, RAB effector). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rabs-5 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (8104284..8107602, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Protein lifeguard 2 Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene ELM2 domain-containing protein Neighboring gene PDZ GRASP-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Endosome maturation factors Rabenosyn-5/VPS45 and caveolin-1 regulate ciliary membrane and polycystin-2 homeostasis. Scheidel N, et al. EMBO J, 2018 May 2. PMID 29572244, Free PMC Article
  2. The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans. Gengyo-Ando K, et al. EMBO Rep, 2007 Feb. PMID 17235359, Free PMC Article
  3. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa A, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16873553, Free PMC Article
  4. DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans. van der Vaart A, et al. PLoS Genet, 2015 Dec. PMID 26657059, Free PMC Article
  5. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in pinocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
FYVE-type domain-containing protein
NP_001294172.1
  • Confirmed by transcript evidence
NP_501352.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8104284..8107602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068951.4 → NP_501352.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501352.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N3Y4
    Conserved Domains (3) summary
    cl28890
    Location:173 → 218
    FYVE_like_SF; FYVE domain like superfamily
    pfam05605
    Location:21 → 47
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam11464
    Location:521 → 557
    Rbsn; Rabenosyn Rab binding domain

  2. NM_001307243.3 → NP_001294172.1  FYVE-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294172.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6SBE5
    Conserved Domains (3) summary
    cl28890
    Location:173 → 218
    FYVE_like_SF; FYVE domain like superfamily
    pfam05605
    Location:21 → 47
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam11464
    Location:523 → 559
    Rbsn; Rabenosyn Rab binding domain
Nucleotide Protein
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