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unc-44 AO66 ankyrin;Ankyrin-2;Trans-sialidase;UNC-44;ZU5 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177366, updated on 2-Nov-2024

Summary

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Official Symbol
unc-44
Official Full Name
AO66 ankyrin;Ankyrin-2;Trans-sialidase;UNC-44;ZU5 domain-containing protein
Primary source
WormBase:WBGene00006780
Locus tag
CELE_B0350.2
See related
AllianceGenome:WB:WBGene00006780
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cell adhesion molecule binding activity. Involved in several processes, including axon guidance; establishment or maintenance of cytoskeleton polarity; and netrin-activated signaling pathway. Located in lateral plasma membrane. Is expressed in several structures, including hermaphrodite gonad; hypodermis; intestine; muscle cell; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); ankyrin-B-related cardiac arrhythmia; autosomal recessive intellectual developmental disorder 37; bipolar disorder; and heart conduction disease (multiple). Orthologous to several human genes including ANK2 (ankyrin 2) and ANK3 (ankyrin 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-44 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
20
Sequence:
Chromosome: IV; NC_003282.8 (5975557..6004857)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutational analysis of the Caenorhabditis elegans ankyrin gene unc-44 demonstrates that the large spliceoform is critical for neural development. Boontrakulpoontawee P, et al. Mol Genet Genomics, 2002 May. PMID 12073031
  2. An ankyrin-related gene (unc-44) is necessary for proper axonal guidance in Caenorhabditis elegans. Otsuka AJ, et al. J Cell Biol, 1995 May. PMID 7744957, Free PMC Article
  3. A Caenorhabditis elegans Model for Integrating the Functions of Neuropsychiatric Risk Genes Identifies Components Required for Normal Dendritic Morphology. Aguirre-Chen C, et al. G3 (Bethesda), 2020 May 4. PMID 32132169, Free PMC Article
  4. UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting. Maniar TA, et al. Nat Neurosci, 2011 Nov 20. PMID 22101643, Free PMC Article
  5. unc-44 Ankyrin and stn-2 gamma-syntrophin regulate sax-7 L1CAM function in maintaining neuronal positioning in Caenorhabditis elegans. Zhou S, et al. Genetics, 2008 Nov. PMID 18791240, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, using the C. elegans PLM neurons as a model, we show that UNC-44/ankyrin acts upstream of UNC-33/CRMP in regulation of a potential kinesin VAB-8 to control gap junction dynamics
    Title: Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.
  2. We suggest that UNC-44 and UNC-33 direct polarized sorting through their global effects on neuronal microtubule organization.
    Title: UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemorepulsion of axon IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal/ventral axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of microtubule cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in localization IEA
Inferred from Electronic Annotation
more info
  
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in netrin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dorsal/ventral axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AO66 ankyrin;Ankyrin-2;Trans-sialidase;UNC-44;ZU5 domain-containing protein
NP_001021266.2
  • Partially confirmed by transcript evidence
NP_001021267.1
  • Confirmed by transcript evidence
NP_001367343.1
  • Confirmed by transcript evidence
NP_001367344.1
  • Confirmed by transcript evidence
NP_001367345.1
  • Confirmed by transcript evidence
NP_001368407.1
  • Confirmed by transcript evidence
NP_001368408.1
  • Confirmed by transcript evidence
NP_001368409.1
  • Confirmed by transcript evidence
NP_500901.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    5975557..6004857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380250.2 → NP_001367343.1  Ankyrin-2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECZ1
    Conserved Domains (8) summary
    smart00218
    Location:1000 → 1104
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02876
    Location:242 → 648
    PHA02876; ankyrin repeat protein; Provisional
    PHA03095
    Location:37 → 387
    PHA03095; ankyrin-like protein; Provisional
    cd08317
    Location:1497 → 1574
    Death_ank; Death domain associated with Ankyrins
    sd00045
    Location:424 → 455
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:756 → 807
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1331 → 1466
    UPA_2; UPA domain
    cl39094
    Location:555 → 780
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001380251.2 → NP_001367344.1  AO66 ankyrin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MQG0
    Conserved Domains (8) summary
    smart00218
    Location:1000 → 1104
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02876
    Location:242 → 648
    PHA02876; ankyrin repeat protein; Provisional
    PHA03095
    Location:37 → 387
    PHA03095; ankyrin-like protein; Provisional
    cd08317
    Location:1497 → 1574
    Death_ank; Death domain associated with Ankyrins
    sd00045
    Location:424 → 455
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:756 → 807
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1331 → 1466
    UPA_2; UPA domain
    cl39094
    Location:555 → 780
    Ank_2; Ankyrin repeats (3 copies)

  3. NM_001380252.2 → NP_001368407.1  Ankyrin-2 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JP86
    Conserved Domains (8) summary
    smart00218
    Location:1008 → 1110
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02876
    Location:242 → 648
    PHA02876; ankyrin repeat protein; Provisional
    PHA03095
    Location:37 → 387
    PHA03095; ankyrin-like protein; Provisional
    cd08317
    Location:1503 → 1580
    Death_ank; Death domain associated with Ankyrins
    sd00045
    Location:424 → 455
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:756 → 807
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1337 → 1472
    UPA_2; UPA domain
    cl39094
    Location:555 → 780
    Ank_2; Ankyrin repeats (3 copies)

  4. NM_001380249.1 → NP_001367345.1  AO66 ankyrin [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17343, Q17490
    Conserved Domains (9) summary
    smart00218
    Location:1008 → 1110
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    PHA02876
    Location:242 → 648
    PHA02876; ankyrin repeat protein; Provisional
    PTZ00449
    Location:1770 → 2112
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03095
    Location:37 → 387
    PHA03095; ankyrin-like protein; Provisional
    cd08317
    Location:1503 → 1580
    Death_ank; Death domain associated with Ankyrins
    sd00045
    Location:424 → 455
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:756 → 807
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1337 → 1472
    UPA_2; UPA domain
    cl39094
    Location:555 → 780
    Ank_2; Ankyrin repeats (3 copies)

  5. NM_001380253.1 → NP_001368408.1  UNC-44 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17341, V6CLS7
    Conserved Domains (3) summary
    smart00218
    Location:167 → 271
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08317
    Location:664 → 741
    Death_ank; Death domain associated with Ankyrins
    pfam17809
    Location:498 → 633
    UPA_2; UPA domain

  6. NM_001380254.1 → NP_001368409.1  UNC-44 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17341, V6CLR6
    Conserved Domains (3) summary
    smart00218
    Location:175 → 277
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08317
    Location:670 → 747
    Death_ank; Death domain associated with Ankyrins
    pfam17809
    Location:504 → 639
    UPA_2; UPA domain

  7. NM_068500.5 → NP_500901.2  ZU5 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_500901.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17341, Q5TYL6
    Conserved Domains (2) summary
    smart00218
    Location:96 → 200
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08317
    Location:593 → 670
    Death_ank; Death domain associated with Ankyrins

  8. NM_001026096.4 → NP_001021267.1  ZU5 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021267.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17342, Q5TYL5
    Conserved Domains (2) summary
    smart00218
    Location:1 → 90
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08317
    Location:483 → 560
    Death_ank; Death domain associated with Ankyrins

  9. NM_001026095.6 → NP_001021266.2  Trans-sialidase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17489
Nucleotide Protein
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