elo-6 Long chain fatty acid elongase 6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: elo-6
Official Full Name: Long chain fatty acid elongase 6
Primary source: WormBase:WBGene00001244
Locus tag: CELE_F41H10.8
See related: AllianceGenome:WB:WBGene00001244
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable fatty acid elongase activity. Predicted to be involved in fatty acid biosynthetic process and sphingolipid biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in amphid neurons; intestine; nerve ring; and vulva. Orthologous to human ELOVL3 (ELOVL fatty acid elongase 3) and ELOVL6 (ELOVL fatty acid elongase 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See elo-6 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (5386629..5388559, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

elo-5 and elo-6 may be transcriptional targets of LPD-1
Title: Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F41H10.9 (e-PCR)
- UniSTS:315752

F41H10.8 (e-PCR)
- UniSTS:314303

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables fatty acid elongase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid elongase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cellular lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid elongation, monounsaturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation, polyunsaturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation, saturated fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methyl-branched fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Long chain fatty acid elongase 6

NP_500797.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

5386629..5388559 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068396.8 → NP_500797.1 Long chain fatty acid elongase 6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500797.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20303

Conserved Domains (1) summary

pfam01151
Location:33 → 262

ELO; GNS1/SUR4 family